Results 61 to 70 of about 27,702,308 (366)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A Mechanical Model and its Experimental Verification for a Water Injection String in a Highly Deviated Well [PDF]

Journal of Petroleum Science and Technology, 2017
Water injection strings in highly deviated wells are subjected to complex forces on the string bore. In this work, a mechanical model is developed for these forces and for those on downhole tools.
Liu Jun, wang wei, Liu You, Zhang Zhong, Xiao hua, Sang Guo   +5 more
doaj   +1 more source

Bio-Chemo-Mechanical Models of Vascular Mechanics [PDF]

Annals of Biomedical Engineering, 2014
Models of vascular mechanics are necessary to predict the response of an artery under a variety of loads, for complex geometries, and in pathological adaptation. Classic constitutive models for arteries are phenomenological and the fitted parameters are not associated with physical components of the wall.
Jungsil, Kim, Jessica E, Wagenseil
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

New In Situ Imaging-Based Methodology to Identify the Material Constitutive Model Coefficients in Metal Cutting Process [PDF]

, 2019
A great challenge of metal cutting modeling is the ability of the material constitutive model to describe the mechanical behavior of the work material under the deformation conditions that characterizes this process.
ZHANG, Xiao-Ming, OUTEIRO, José, ZHANG, Ke, ZHANG, Dong, DING, Han, MARTINS DO OUTEIRO, Jose Carlos   +5 more
core   +1 more source

A model with contact maps at both polymer chain and network scales for tough hydrogels with chain entanglement, hidden length and unconventional network topology

, 2023
Tough hydrogels with unconventional polymer network architectures often show superior mechanical properties because of the microstructures at the polymer chain and network scales.
Li, Hua, Hua Li, Lam, Khin Yong, Hao You, Zheng, Shoujing, You, Hao, Shoujing Zheng, K.Y. Lam   +7 more
core   +1 more source

Mechanical properties and dynamic breaking mechanism of plateau frozen soil

Geomatics, Natural Hazards & Risk, 2023
This work studies and evaluates the mechanical properties of frozen soil, FS, from Yulong mine in Tibet, under different freezing temperatures ranging from −12 °C to −1 °C, using experimental tests. In addition, the effects of temperature and time on the
Fuqiang Ren, Changhao Hao, Bo Sun, Zhenyang Xu   +3 more
doaj   +1 more source

A mechanical model for phase separation in debris flow [PDF]

International Journal of Multiphase Flow, 2016
Understanding the physics of phase-separation between solid and fluid phases as a mixture mass moves down slope is a long-standing challenge. Here, we propose an extension of the two phase mass flow model (Pudasaini, 2012) by including a new mechanism ...
S. Pudasaini, J. Fischer
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source