Results 81 to 90 of about 27,702,308 (366)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
A simple state-based prognostic model for railway turnout systems [PDF]
, 2010 The importance of railway transportation has been increasing in the world. Considering the current and future estimates of high cargo and passenger transportation volume in railways, prevention or reduction of delays due to any failure is becoming ever ...
Baskan, Saim +5 more
core +1 more source
Experimental Study on Local Bearing Capacity of Concrete Reinforced with Spiral Stirrups
BuildingsTo investigate the local compressive bearing capacity of concrete reinforced with spiral stirrups, a study was conducted on 40 specimens, focusing on the analysis of failure modes and strain variations.
Hongbo Li +9 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Connecting Diffusion Tensor Information with Mechanical Anisotropy of a Hyper-Viscoelastic Constitutive Model for Brain Tissue [PDF]
, 2012 This study aims to test the mechanical behavior of a hyper-viscoelastic fiber-reinforced material for brain tissue which accounts for anisotropic features of the brain thereby exploiting imaging.
Giordano, Chiara
core
Механика машин, механизмов и материалов, 2009 The mathematical and mechanical model of the reconstructed middle ear subjected to tympanoplasty by using the "large island" technique is constructed. The restored tympanic membrane (TM) is modeled as the system of two concentrically conjugate annular ...
G.I. Mikhasev , S.A. Ermochenko
doaj
河南理工大学学报. 自然科学版ObjectivesTo address the problems of severe roadway surrounding damage and poor stability during mining of complex-structure coal seams， the failure mechanism of coal pillars under roadway stress was investigated， taking the 10103 face of Baozigou Coal ...
Niu Haiping +4 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Model-free tracking control of an optical fiber drawing process using deep reinforcement learning
, 2020 Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020Cataloged from the PDF version of thesis.Includes bibliographical references (pages 73-76).A deep reinforcement learning (DRL) approach for tracking ...
Kim, Sangwoon, (Mechanical engineer) Massachusetts Institute of Technology.
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source