Results 141 to 150 of about 995,645 (283)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Altered Mechanical Properties of Astrocytes Lacking MLC1: Implications for the Leukodystrophy MLC. [PDF]

Glia
Bisseling Q, Passchier EMJ, Kirwan FM, Antonovaite N, Camerini S, Brignone MS, Freal A, Mansvelder HD, Ambrosini E, van der Knaap MS, Min R.   +10 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Effect of Pattern Addition on the Mechanical Properties of 3D-Printed Parts. [PDF]

Polymers (Basel)
Anaç N, Koçar O.
europepmc   +1 more source

Development of bio-based earth products for healthy and sustainable buildings: characterization of microbiological, mechanical and hygrothermal properties

, 2015
Alexis Simons, Aurélie Laborel-Préneron, Alexandra Bertron, Jean‐Emmanuel Aubert, Camille Magniont, Christophe Roux, Christine Roques   +6 more
openalex   +1 more source

MECHANICAL PROPERTIES OF THE NEW KETAC™ UNIVERSAL GLASS IONOMER RESTORATIVE MATERIAL: EFFECT OF RESIN COATING [PDF]

, 2017
Tarek Soliman, Maha Othman
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Unveiling the Compression Mechanical Properties of AMPS-APTAC-DMAAm Terpolymeric Hydrogels. [PDF]

Gels
Mussalimova M, Gizatullina N, Yelemessova G, Taubatyrova A, Aitkaliyeva G, Shynykul Z, Su E, Toleutay G.   +7 more
europepmc   +1 more source

Mechanical and crystallographic properties of injection‐molded polyamide 66/sepiolite nanocomposites with different clay loading

, 2014
Cristina Fernández-Barranco, África Yebra‐Rodríguez, M. Dolores La Rubia, Francisco J. Navas‐Martos, Pedro Álvarez‐Lloret   +4 more
openalex   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source