Results 41 to 50 of about 779,679 (267)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Mechanical Response of Random Heteropolymers [PDF]

Macromolecules, 2002
10 pages, 6 ...
Geissler, Phillip L., Shakhnovich, Eugene I.   +1 more
openaire   +2 more sources

Mechanical Stretch α‐Cyclodextrin Pseudopolyrotaxane Elastomer with Reversible Phosphorescence Behavior

Advanced Science
Polyethylene glycol chains in two terminals of the naphthalene functional group are threaded into α‐cyclodextrin cavities to form the pseudopolyrotaxane (NPR), which not only effectively induces the phosphorescence of the naphthalene functional group by ...
Yi Zhang, Yong Chen, Jian‐Qiu Li, Song‐En Liu, Yu Liu   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Multi-Branch Towed Array System: Systematic Analysis of Modeling Methods, Environmental Responses and Mechanical Properties in Fracture Analysis

Journal of Marine Science and Engineering
Multi-branch towed array systems are an important component of subsea information collection, which is increasingly required for subsea pipeline laying and offshore platform construction as ocean energy is exploited. However, the complexity of underwater
Jin Yan, Kefan Yang, Shengqing Zeng, Keqi Yang, Dapeng Zhang, Keqiang Zhu   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Analysis of Local Damages Effect on Mechanical Responses of Underwater Shield Tunnel via Field Testing and Numerical Simulation

Applied Sciences, 2020
The investigation of concrete structural performance is crucial to maintain the stability of infrastructure. In order to assess structural stability, this work focuses on the development of an integrated framework to detect damaged conditions in the ...
Xuyan Tan, Weizhong Chen, Luyu Wang, Jianping Yang   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mechanical Responses of 3D Printed Periodic Arch-Inspired Structures Doped with NdFeB Powder

Mathematics
This work explores the mechanical responses of 3D-printed periodic arch-inspired structures (PASs) and PASs doped with NdFeB powder to advance their application in lightweight structural load-bearing and future structure–function integration.
Yangsen Wang, Bin Huang, Yan Guo
doaj   +1 more source