Results 51 to 60 of about 779,679 (267)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Neurobiological Mechanisms of Placebo Responses [PDF]
Annals of the New York Academy of Sciences, 2009 Expectations, positive or negative, are modulating factors influencing behavior. They are also thought to underlie placebo effects, potentially impacting perceptions and biological processes. We used sustained pain as a model to determine the neural mechanisms underlying placebo‐induced analgesia and affective changes in healthy humans.
Jon-Kar, Zubieta, Christian S, Stohler
openaire +2 more sources
MoleculesThe mechanical response is one of the main factors that influence the capacity and number of cycles of lithium batteries, which hinder its wide application.
Zheru Shen +3 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Mechanisms of cholangiocyte responses to injury
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018 Cholangiocytes, epithelial cells that line the biliary epithelium, are the primary target cells for cholangiopathies including primary sclerosing cholangitis and primary biliary cholangitis. Quiescent cholangiocytes respond to biliary damage and acquire an activated neuroendocrine phenotype to maintain the homeostasis of the liver. The typical response
Keisaku Sato +4 more
openaire +2 more sources
Influence of medium adhesion on the mechanical response of PDC impacts
Functional DiamondPolycrystalline diamond compact (PDC) drill bits are widely employed in ultra-deep oil and gas drilling operations. However, their performance is significantly compromised by mud packing phenomena, primarily caused by rock chip adhesion during impact ...
Dezhong Meng +5 more
doaj +1 more source
Mechanical Response of Deep Soft-Rock Tunnels Under Different Rock Bolt Configurations: Model Tests
BuildingsDeep soft-rock tunnels are prone to large deformations and structural damage. This study used the Guanyinping Tunnel as a prototype and conducted 1/50-scale progressive loading model tests under three support configurations: rock-bolt-free, equal-length ...
Yue Yang
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Virtual and Physical PrototypingTo overcome the trade-off between strength and energy absorption capacity inherent in conventional single-topology lattices, a novel hybrid lattice structure, SC-Flu, combining SC (simple cubic) and Flu (fluorite) topologies, was proposed and fabricated ...
Jingjing Cai +3 more
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source