Results 71 to 80 of about 779,679 (267)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Numerical Analysis of Reinforced Concrete Frame Structures with Graphene Oxide and Study of the Earthquake-Resistant Behavior of the Structures Considering the Earthquake in Turkey and Syria (2023)

Fibers
The earthquake of 6 February 2023, in Turkey and Syria, was catastrophic for many existing buildings. Various reasons have been given to try to understand what happened, since after 2000, changes in construction methods were introduced in this area, with
D. Domínguez-Santos
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Mechanisms responsible for coronary vasospasm

Journal of the American College of Cardiology, 1986
Studies have been conducted on isolated segments of the left circumflex coronary artery of the dog to gain information on the mechanism or mechanisms of vasospasm. Coronary arteries contain both postjunctional alpha 1- and beta 1-adrenoceptors, and both are accessible to norepinephrine released from the sympathetic nerves.
Shepherd, T, Vanhoutte, PM
openaire   +4 more sources

Influence of built-in strain sensor on the mechanical properties of asphalt mixture

工程科学学报
The pursuit of intelligence and smartness in road infrastructure is critical for the advancement of road engineering. Embedded strain sensors serve as a vital tool for sensing strain within pavement structures.
Li LIU, Li LI, Zhaohui LIU, Shunfa FU, Wenbo LI, Houxuan PAN   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Mechanical response characteristics and damage mechanism of water-containing mudstone under low strain rate dynamic loading

Meitan xuebao
Accelerated instability and failure of surrounding water-rich mudstone in roadway under dynamic loading has become a prominent problem in deep coal resource mining, and it is of great significance to study the damage mechanism of water-containing ...
Guichen LI, Sen YANG, Yuantian SUN, Jinghua LI, Haoran HAO, Zeyu SHAO   +5 more
doaj   +1 more source

Mechanical response of large-diameter shield tunnels during assembly

Yantu gongcheng xuebao, 2019
Based on loading analysis of shield tunnel segments during the assembly phase, a finite difference model is established for segmental lining structure in assembly stage.
FENG Kun 1, XU Kai 1, PENG Zu-zhao 2, ZHOU Zi-yang 1, HE Chuan 1, XIAO Ming-qing 3
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source