Results 91 to 100 of about 506,255 (288)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A perspective on the control of FES-supported standing [PDF]

, 1998
This special section is about the control of electrical stimulators to restore standing functions to paraplegics. It addresses several important topics regarding the interactions of the intact central nervous systems (CNS) with the artificial control ...
Donaldson, Nick, Veltink, Peter H.
core   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A Novel Superparamagnetic‐Responsive Hydrogel Facilitates Disc Regeneration by Orchestrating Cell Recruitment, Proliferation, and Differentiation within Hostile Inflammatory Niche

Advanced Science
In situ disc regeneration is a meticulously orchestrated process, which involves cell recruitment, proliferation and differentiation within a local inflammatory niche.
Borui Xue, Yan Peng, Yongfeng Zhang, Shijie Yang, Yi Zheng, Huiling Hu, Xueli Gao, Beibei Yu, Xue Gao, Shengyou Li, Haining Wu, Teng Ma, Yiming Hao, Yitao Wei, Lingli Guo, Yujie Yang, Zhenguo Wang, Tingfeng Xue, Jin Zhang, Beier Luo, Bing Xia, Jinghui Huang   +21 more
doaj   +1 more source

Slime mould tactile sensor [PDF]

, 2013
Slime mould P. polycephalum is a single cells visible by unaided eye. The cells shows a wide spectrum of intelligent behaviour. By interpreting the behaviour in terms of computation one can make a slime mould based computing device.
Adamatzky, Andrew
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Engineering living root with mechanical stimulation derived from reciprocating compression in a double network hydrogel as elastic soil

Advanced Agrochem
The root system actively reacts to mechanical stimuli in its environment, transmitting mechanical signals to optimize the utilization of environmental resources.
Qiye Wu, Jinchun Xie, Junfu Li, Yongjun Men   +3 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Frequency and Resting Time Dependencies of Electrically-Induced Muscle Contraction Force

Journal of Biomechanical Science and Engineering, 2009
Physical exercise is a promising countermeasure for osteoporosis and strengthens skeletal muscle as well, resulting in a reduction of the risk of fall.
Shigeo M. TANAKA, Kanako KONDO
doaj   +1 more source

Modulation of Negative Work Output from a Steering Muscle of the Blowfly Calliphora Vicina [PDF]

, 1994
Of the 17 muscles responsible for flight control in flies, only the first basalar muscle (b1) is known to fire an action potential each and every wing beat at a precise phase of the wing-beat period.
Dickinson, Michael H., Tu, Michael S.
core