Results 111 to 120 of about 3,260,986 (243)

Biaxial cell stimulation: A mechanical validation.

, 2009
To analyse mechanotransduction resulting from tensile loading under defined conditions, various devices for in vitro cell stimulation have been developed.
Ahrens, S., Wilkening, U., Thompson, MS, Thompson, Mark, Mundlos, S, Ott, C.E., Wilkening, U, Schaser, KD, Mundlos, S., Ott, CE, Seidel, R, Duda, GN, Epari, Devakara R., Bieler, F.H., Thompson, M.S., Schaser, K.D., Epari, DR, Duda, G.N., Bieler, FH, Ahrens, S, Seidel, R.   +20 more
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Feedback control of unsupported standing in paraplegia. Part I: optimal control approach [PDF]

, 1997
This is the first of a pair of papers which describe an investigation into the feasibility of providing artificial balance to paraplegics using electrical stimulation of the paralyzed muscles. By bracing the body above the shanks, only stimulation of the
Hunt, K.J., Donaldson, N., Munih, M.
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Focal mechanical vibration motor effects on the finger tapping in healthy volunteers

Frontiers in Sports and Active Living
IntroductionFocal mechanical vibration is a therapeutic intervention based on oscillatory mechanical vibrations applied to specific anatomical structures.
Tommaso Di Libero, Angelo Rodio, Chiara Carissimo, Gianni Cerro, Cecilia Provenzale, Annalisa D’Ermo, Guido Maria Filippi, Vito Enrico Pettorossi, Luigi Ferrigno, Enrico Marchetti, Luigi Fattorini   +10 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Systemic Administration of Docosahexaenoic Acid Suppresses Trigeminal Secondary Nociceptive Neuronal Activity in Rats

International Journal of Translational Medicine
Background and Objectives: Docosahexaenoic acid (DHA) has been shown to modulate various voltage-gated ion channels and both excitatory and inhibitory synapses. Nonetheless, its exact effect on nociceptive signaling in the trigeminal system has yet to be
Hanano Takahashi, Yukito Sashide, Mamoru Takeda   +2 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

The sensitivity of articular chondrocytes to dynamic mechanical stimulation

, 2016
Thesis (Ph.D, Mechanical and Materials Engineering) -- Queen's University, 2015-12-22 12:11:56.739Chondrocyte sensitization and desensitization to mechanical stimuli are complex phenomena that can limit the effectiveness of mechanical stimulation in
Weber, Joanna
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