Results 141 to 150 of about 1,725,788 (328)

Identifying differential gene expression induced by mechanical stress in cartilage of human explants using RNA-sequencing [PDF]

, 2021
E. Houtman, Margo Tuerlings, Janne Riechelman, H. Eka D. Suchiman, Rob G. H. H. Nelissen, Y.F. Ramos, Rodrigo Coutinho de Almeida, Ingrid Meulenbelt   +7 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Force-Loaded Cementocytes Regulate Osteoclastogenesis Via S1p/S1pr1/ Rac1 Axis

International Dental Journal
Aim or purpose: This study elucidates the pivotal role of the sphingosine-1-phosphate (S1P)/S1PR1/Rac1 axis in cementocyte-regulated osteoclastogenesis during orthodontically induced inflammatory root resorption (OIIRR).
Han Wang
doaj   +1 more source

Mechanical Stressing of Integrin Receptors Induces Enhanced Tyrosine Phosphorylation of Cytoskeletally Anchored Proteins [PDF]

, 1998
Christian Schmidt, Hagen Pommerenke, Frieda Dürr, Barbara Nebe, Joachim Rychly   +4 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Development of Primary Cell Cultures from Haplochromine Cichlid Bone-Derived Tissues

Fishes
Bone is a dynamic tissue with ecological and evolutionary importance, as it can grow and remodel itself in response to mechanical stimuli. In mammals, osteocytes are widely recognised as the central regulators of bone formation and mechanotransduction ...
Deepti Negi, Penelope M. Tsimbouri, Matthew J. Dalby, Kevin J. Parsons   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Research progress on the role of biomechanical clues in the progression of lung cancer

Frontiers in Cell and Developmental Biology
Cells in mammals perceive and react to the mechanical properties of their surrounding environment. Disease progression is frequently linked to dynamic changes in cellular and tissue mechanics.
Fengying Gong, Fengying Gong, Qiang Zhang, Qin Fan, Rongmei Qu, Congrong Wang, Ting Yang, Tingyu Fan, Ying Lv, Jingxing Dai   +9 more
doaj   +1 more source

Reliability approach to rotating-component design [PDF]

A probabilistic methodology for designing rotating mechanical components using reliability to relate stress to strength is explained. The experimental test machines and data obtained for steel to verify this methodology are described. A sample mechanical
Kececioglu, D. B., Lalli, V. R.
core   +1 more source

Orientation of the stress field surrounding the creeping section of the San Andreas Fault: Evidence for a narrow mechanically weak fault zone [PDF]

, 2001
Ann‐Sophie Provost, Heidi Houston
openalex   +1 more source