Results 251 to 260 of about 1,725,788 (328)

ATR senses mechanical stress [PDF]

Nature Reviews Molecular Cell Biology, 2014
openaire   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Study of Podoplanin-Deficient Mouse Bone with Mechanical Stress. [PDF]

Dent J (Basel)
Kanai T, Osawa K, Kajiwara K, Sato Y, Sawa Y.   +4 more
europepmc   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

In vitro analysis of the sealing ability of different root canal sealers under thermo-mechanical stress. [PDF]

Bioinformation
Azad A, Mashalkar V, Agrawal R, Fu Y, Chaudhari D, Haldia A, Mehta M.   +6 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Mechanical stress-induced autophagy is cytoskeleton dependent. [PDF]

Cell Prolif
Liu L, Zheng W, Wei Y, Li Q, Chen N, Xia Q, Wang L, Hu J, Zhou X, Sun Y, Li B.   +10 more
europepmc   +1 more source

Study on Static and Dynamic Mechanical Properties of Polyvinyl Alcohol Fiber Epp Concrete as Buffer Layer of High Geo-Stress Soft Rock Tunnel

Junfu Lu, Minrui Li, Kui Wang, Yunpeng Hu   +3 more
openalex   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Hypoxia- and mechanical stress-induced upregulation of mitochondrial HSP60 is associated with phenotypic switching of pulmonary arterial smooth muscle cells. [PDF]

Cell Stress Chaperones
Liu G, Nie H, Zhang X, Huang ZS, Yoshiura KI, Liu KX, Liu Y, Li TS.   +7 more
europepmc   +1 more source