Results 131 to 140 of about 1,697,500 (308)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Guidelines for ex vivo mechanical testing of tendon. [PDF]

J Orthop Res, 2023
Lake SP, Snedeker JG, Wang VM, Awad H, Screen HRC, Thomopoulos S.   +5 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Non-destructive evaluation of defects in thermal barrier coating system using combined electromagnetic and thermographic signals

Nature Communications
Thermal barrier coating system plays key role in high temperature gas turbine blades. During the manufacture and in-service processes, defects are inevitable due to the inconsistent deformation and fatigue loading. The typical defects, e.g.
Jialun Li, Zongfei Tong, Qingning Yang, Jiahao Wang, Chenyu Jia, Wei Guo, Yuange Zhang, Peng Jiang, Wei Qiu, Tetsuya Uchimoto, Shejuan Xie, Zhenmao Chen, Tiejun Wang   +12 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Digital Shearography for NDE of Crack Classification in Composite Materials

Applied Sciences
This paper presents a relevant and timely study on the application of thermal loaded digital shearography for crack classification in glass fiber reinforced plastic (GFRP) structures, particularly air-cooled condenser (ACC) fan blades.
Zhongfang Gao, Siyuan Fang, Riad Dandan, Lianxiang Yang   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Experimental and Numerical Study of a Turbulent Multiple Jets Issued from Lobed Diffusers

Journal of Applied Fluid Mechanics, 2019
A combined experimental and computational study of a turbulent multiple jet from lobed diffusers is performed. The main interest of these multiple lobed jets is to come up with the best configuration that improves the thermal and dynamic homogenization ...
W. Medaouar, L. Loukarfi, M. Braikia, A. Khelil, H. Naji   +4 more
doaj  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Ranking Technologies of Additive Manufacturing of Removable Complete Dentures by the Results of Their Mechanical Testing. [PDF]

Dent J (Basel), 2023
Grachev DI, Zolotnitsky IV, Stepanov DY, Kozulin AA, Mustafaev MS, Deshev AV, Arutyunov DS, Tlupov IV, Panin SV, Arutyunov SD.   +9 more
europepmc   +1 more source