Results 131 to 140 of about 1,690,858 (288)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Development and Experimental Study of an Experimental Setup for an Online Vibrating Tube Liquid Densitometer

Applied Sciences
Density is a crucial parameter for quantitatively describing the physical properties of liquids. It serves as an important indicator for scientific research, production process control, pipeline transportation, and other aspects.
Defu Xu, Yaoning Sun, Welin Chen, Jun Mu, Wang Peng   +4 more
doaj   +1 more source

An inventory of aeronautical ground research facilities. Volume 1: Wind tunnels [PDF]

A survey of wind tunnel research facilities in the United States is presented. The inventory includes all subsonic, transonic, and hypersonic wind tunnels operated by governmental and private organizations.
Brown, K. R., Hardin, R. D., Heckart, M. V., Pirrello, C. J.   +3 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Non-destructive evaluation of defects in thermal barrier coating system using combined electromagnetic and thermographic signals

Nature Communications
Thermal barrier coating system plays key role in high temperature gas turbine blades. During the manufacture and in-service processes, defects are inevitable due to the inconsistent deformation and fatigue loading. The typical defects, e.g.
Jialun Li, Zongfei Tong, Qingning Yang, Jiahao Wang, Chenyu Jia, Wei Guo, Yuange Zhang, Peng Jiang, Wei Qiu, Tetsuya Uchimoto, Shejuan Xie, Zhenmao Chen, Tiejun Wang   +12 more
doaj   +1 more source

Ranking Technologies of Additive Manufacturing of Removable Complete Dentures by the Results of Their Mechanical Testing. [PDF]

Dent J (Basel), 2023
Grachev DI, Zolotnitsky IV, Stepanov DY, Kozulin AA, Mustafaev MS, Deshev AV, Arutyunov DS, Tlupov IV, Panin SV, Arutyunov SD.   +9 more
europepmc   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Mechanical testing and comparison of porcine tissue, silicones and 3D-printed materials for cardiovascular phantoms. [PDF]

Front Bioeng Biotechnol, 2023
Illi J, Ilic M, Stark AW, Amstutz C, Burger J, Zysset P, Haeberlin A, Gräni C.   +7 more
europepmc   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source