Results 191 to 200 of about 1,690,858 (288)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Finite element analysis of mandibular fracture fixation authenticated by 3D printed mandible mechanical testing. [PDF]

Sci Rep
Daqiq O, van Minnen B, Spijkervet FKL, Wubs FW, Lunter G, Roossien CC.   +5 more
europepmc   +1 more source

Mechanical testing of cephalomedullary nail lag screws after the addition of hydroxyapatite substitutes. [PDF]

OTA Int, 2021
Nakajima T, Aoki Y, Watanabe A, Inoue M, Yamaguchi S, Nakamura J, Matsuura Y, Hagiwara S, Himeno D, Ohtori S.   +9 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Tuning and validation of a virtual mechanical testing pipeline for condylar stress fracture risk assessment in Thoroughbred racehorses. [PDF]

R Soc Open Sci
Irandoust S, Whitton C, Henak C, Muir P.
europepmc   +1 more source

Correction: Using mechanical testing to assess texturing of prosthetic sockets to improve suspension in the transverse plane and reduce rotation. [PDF]

PLoS One, 2022
Quinlan J, Subramanian V, Yohay J, Poziembo B, Fatone S.   +4 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Flammability and Mechanical Testing of Sandwich Composite for Rolling Stock Structural Applications. [PDF]

Materials (Basel)
Kalinowski M, Szczepanik M, Szymiczek M.
europepmc   +1 more source

Mechanical Testing of the New Cage for Tibial Tuberosity Advancement with the Cranial Implant Fixation (TTA CF) Technique-Ex Vivo Study on Sheep Model. [PDF]

Animals (Basel), 2022
Zhalniarovich Y, Przyborowska-Zhalniarovich P, Tobolska A, Mieszkowska M, Abako J, Morawska-Kozłowska M, Mieszkowski M, Onichimowski D.   +7 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source