Results 101 to 110 of about 322,239 (306)

An Expanded Access Protocol of RNS60 in Amyotrophic Lateral Sclerosis

Muscle &Nerve, Volume 72, Issue 1, Page 124-129, July 2025.
ABSTRACT Aims RNS60 is an investigational product in clinical development for amyotrophic lateral sclerosis (ALS). RNS60 slowed disease progression in the ALS SOD1G93A mouse model and was safe and well tolerated both in an open‐label pilot study and a randomized, placebo‐controlled, multicenter phase 2 trial in people living with ALS.
Grace Addy, Erica Scirocco, Dario Gelevski, Margot Rohrer, Aimee Roderick, Mary McCormack, Anat Weiss Sadan, Jennifer Scalia, Neil Parikh, Elisa Giacomelli, Matteo Locatelli, Dylan V. Neel, Derek D'Agostino, Alex Leite, Hong Yu, Alexander V. Sherman, Jarrad Mock, Andreas Kalmes, Sarah Luppino, Suma Babu, James Berry, Merit Cudkowicz, Sabrina Paganoni   +22 more
wiley   +1 more source

Doppler echocardiographic assessment of left ventricular diastolic function in chronic hypoxic rats [PDF]

, 2009
Little information is available on the mechanism of diastolic left ventricular (LV) dysfunction in patients with chronic respiratory disease complicated by hypoxia.
Itoh, Atsushi, Sano, Shunji, Tomita, Hideshi   +2 more
core   +1 more source

Intravenous Thrombolysis in Patients Taking Direct Oral Anticoagulation Treatment Before Stroke Onset: Results from the Safe Implementations of Treatments in Stroke International Stroke Registry

Annals of Neurology, Volume 97, Issue 6, Page 1205-1214, June 2025.
Objectives Intravenous thrombolysis (IVT) is contraindicated for acute ischemic stroke (AIS) patients taking direct oral anticoagulants (DOACs) within 48 hours before index stroke. Limited data exist on off‐label use of IVT for these patients. We compared the safety and outcomes of IVT in AIS patients with DOAC treatment and patients with no OAC before
Marius Matusevicius, Malin Säflund, Maurizio Balestrino, Manuel Cappellari, Delfina Ferrandi, Abdoreza Ghoreishi, André Peeters, Viiu‐Marika Rand, Manuela De Michele, Aleksandras Vilionskis, Andrea Zini, Niaz Ahmed   +11 more
wiley   +1 more source

Impact of Etiology, Thrombectomy Techniques, and Lesion Localization on Endovascular Treatment Success in Acute Basilar Artery Occlusion: A Single‐Center Retrospective Study

Brain and Behavior, Volume 15, Issue 6, June 2025.
In acute basilar artery occlusion, endovascular treatment achieved 100% recanalization, with lower 3‐month mRS observed in the cardioembolic group and those treated with combined techniques despite longer procedure times. Larger, randomized controlled studies are needed to confirm and clarify the strength of our findings.
Halil Alper Eryilmaz, Sena Boncuk Ulaş, Bilgehan Atılgan Acar   +2 more
wiley   +1 more source

Towards a Computed Collateral Circulation Score in Ischemic Stroke [PDF]

arXiv, 2020
Stroke is the second leading cause of disability worldwide. In order to minimize disability, the goal of stroke treatment is to preserve tissue in the area where blood supply is decreased but sufficient to stave off cell death. Thrombectomy has been shown to offer fast and efficient reperfusion with high recanalization rates.
arxiv  

Mechanical thrombectomy for acute ischaemic stroke [PDF]

South African Medical Journal, 2019
Rapid, safe and effective arterial recanalisation to restore blood flow and improve functional outcome is the primary goal of hyperacute management of acute ischaemic stroke. This is possible either through thrombolysis or direct mechanical removal of clot from the blocked artery.
openaire   +4 more sources

Massive Acute Thrombosis of a Mechanical Mitral Valve in a Young Patient on Acenocoumarin: A Case Report Comparing Surgical and Thrombolytic Approaches

Clinical Case Reports, Volume 13, Issue 6, June 2025.
ABSTRACT Obstructive mechanical mitral valve thrombosis is a life‐threatening emergency requiring urgent intervention. Surgery is often first‐line; thrombolysis may be considered in high‐risk cases. A multidisciplinary approach is essential to balance thromboembolic and bleeding risks, emphasizing early recognition, optimized anticoagulation, and ...
Said Khallikane, Bassam Bencharfa, Noureddine Atmani, Abdessamad Abdou, Ayoub Belhadj, Younes Aissaoui   +5 more
wiley   +1 more source

Simultaneous radiation pressure induced heating and cooling of an opto-mechanical resonator [PDF]

, 2012
Cavity opto-mechanics enabled radiation-pressure coupling between optical and mechanical modes of a micro-mechanical resonator gives rise to dynamical backaction, enabling amplification and cooling of mechanical motion. Due to a combination of large mechanical oscillations and necessary saturation of amplification, the noise floor of the opto ...
arxiv   +1 more source

Jefferson Digital Commons quarterly report: January-March 2020 [PDF]

, 2020
This quarterly report includes: New Look for the Jefferson Digital Commons Articles COVID-19 Working Papers Educational Materials From the Archives Grand Rounds and Lectures JeffMD Scholarly Inquiry Abstracts Journals and Newsletters Master of Public ...
Copeland, LIBT, James, Duinkerken, MSI, Kelsey, Gordon, MSLIS, MEd, MA, Larissa   +2 more
core   +1 more source

Knee joint dislocations—Current epidemiology and treatment in Germany

Knee Surgery, Sports Traumatology, Arthroscopy, Volume 33, Issue 6, Page 2114-2121, June 2025.
Abstract Purpose Knee joint dislocations, though rare, present significant challenges due to potential complications like vascular and nerve damage, and are known to be often linked to sports injuries, accidents and obesity. This study aims to analyse the epidemiology, incidence and treatment approaches for knee dislocations in Germany from 2019 to ...
Johannes Weber, Dominik Szymski, Lorenz Huber, Josina Straub, Volker Alt, Julia Elisabeth Lenz   +5 more
wiley   +1 more source