Results 121 to 130 of about 2,607,441 (255)

Highly potent, brain‐penetrant EP2 receptor antagonists for the treatment of permanent focal cerebral ischaemia in male and female mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cerebral ischaemia is a leading cause of death in older adults and imposes a substantial global economic burden. Recent studies indicate that inhibiting the Gαs‐coupled EP2 receptor reduces ischaemic brain injury by modulating neuroinflammation.
Zhen Jin, Chenyao Jiang, Eun Bee Cho, M. Dennis Leo, Jiukuan Hao, Jiawang Liu, Ying Yu, Jianxiong Jiang   +7 more
wiley   +1 more source

Treatment of Acute Ischemic Stroke: IV Thrombolysis and Beyond [PDF]

, 2011
Intravenous thrombolysis using tissue plasminogen activator is an approved treatment of acute ischemic stroke. However, it has limitation of short therapeutic time window and hemorrhagic complications. This review provides an update of current treatment
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core  

Utility of the SWAM (Separator With Aspirator for Mechanical Thrombectomy) Device in Managing Hemodialysis Access Thrombosis

Hemodialysis International, EarlyView.
ABSTRACT Background Hemodialysis access thrombosis is the primary cause of access failure. Thrombus removal is an effective strategy to restore access function. Although both open surgical and endovascular procedures enable thrombus clearance, endovascular thrombus reduction therapy is widely adopted in clinical practice for this condition due to its ...
Lin Li, Zhongwang Zhang, Hongjie Wang, Mingdi Zhu, Kun Wang, Zheng Liu   +5 more
wiley   +1 more source

Thrombolysis for Venous Thromboembolism During Pregnancy: A Literature Review

, 2018
Background: Pregnancy is a hypercoagulable state, conferring an increased risk of venous thromboembolism (VTE). However, treatment algorithms for deep venous thrombosis and pulmonary embolism are based on studies of nonpregnant patients.
Christina Rao, Kara Rothenberg, Sapan S. Desai, Vy T. Ho, Kedar Lavingia, Anahita Dua   +5 more
core   +1 more source

Lead‐Associated Superior Vena Cava Syndrome: Diagnostic Delay and the Role of Invasive Pressure Measurements

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Superior vena cava (SVC) syndrome is an uncommon complication of transvenous cardiac device leads. Diagnosis may be challenging due to gradually developing and nonspecific symptoms. Furthermore, anatomical imaging does not always reflect the hemodynamic significance of venous stenosis.
Fenna Daniëls, Hessel F. Groenveld, Erik Lipšic, Reinoud P. H. Bokkers, Michiel Rienstra, Alexander H. Maass   +5 more
wiley   +1 more source

Management of Left Atrial Appendage Thrombi and Spontaneous Echo Contrast

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background To analyze the efficacy and safety of various anticoagulation strategies/regimen used for managing thrombus or spontaneous echo contrast in the left atrial appendage. Methods Thrombus or spontaneous echo contrast in the left atrial appendage was detected via transesophageal echocardiography in 83 patients, most often during a stroke
Timnou Bekouti Jean, Ravakiniaina Ranaivosoa Mialy, Ateba Ateba Nelly Stella, Tsague Kegni Hermann, Rambolarimanana Mansh, Ndobo Julia Valérie, Imbey Eheth Levy, Maury Philippe, Diawara Alpha, Roynard Jean Louis, Boombhi Jerome Hilaire   +10 more
wiley   +1 more source

Ultraslow Thrombolysis of Mechanical Tricuspid Prosthetic Thrombosis

JACC: Case Reports
Prosthetic heart valve implantation over the past 7 decades has revolutionized treatment of valvular heart disease. Mechanical heart valves, although more durable than a bioprosthesis, require lifelong anticoagulation, with risk of valve thrombosis-a serious, life-threatening complication with high morbidity and mortality.We present a case of ...
Afzal, Uzma, Lau, Jeffery, Yap, Jonathan, Fam, Jiang Ming, Ooi, Inn Jia, Anbalakan, Kamalesh, Tan, Ju Le, Ding, Zee Pin, Ewe, See Hooi, Ho, Kay Woon   +9 more
openaire   +3 more sources

Mechanical Thrombectomy Outcomes With and Without Intravenous Thrombolysis in Stroke Patients

, 2017
Background and Purpose— Whether prior intravenous thrombolysis provides any additional benefits to the patients undergoing mechanical thrombectomy for large vessel, acute ischemic stroke remains unclear.
Robert F. James, Rohan V. Chitale, Matthew R. Fusco, Akshitkumar M. Mistry, John J. Volpi, Mohammad Obadah Nakawah, Eva A. Mistry   +6 more
core   +1 more source

Epidemiological characteristics and pre‐hospital treatment outcomes of pre‐hospital emergency patients in the main urban area of Chongqing, 2024–2025

Hong Kong Journal of Emergency Medicine, Volume 33, Issue 6, December 2026.
Abstract Background Pre‐hospital emergency care is a critical component of emergency medical services (EMS), yet large‐scale epidemiological evidence from the main urban area of Chongqing remains limited. This study aimed to characterize the epidemiological profile and pre‐hospital outcomes of emergency patients in Chongqing from 2024 to 2025 and to ...
Liujiang Ran, Jun Si, Yanyan Liu
wiley   +1 more source

A Voxel‐Wise T2 Distribution Framework for Lesion Severity Stratification and Treatment‐Response Assessment in Stroke: Insights Into Suberoylanilide Hydroxamic Acid‐Induced Neuroprotection

Magnetic Resonance in Medicine, Volume 96, Issue 6, Page 2870-2884, December 2026.
ABSTRACT Purpose To evaluate lesion severity distribution in ischaemic brain lesions in spontaneously hypertensive rats (SHR) subjected to 90‐min transient middle cerebral artery occlusion (tMCAO), and to determine whether epigenetically based neuroprotection modifies lesion severity profiles using a voxel‐wise T2 distribution framework.
Andrea Díaz‐Pérez, Clara Penas, Francesc Jiménez‐Altayó, Silvia Lope‐Piedrafita   +3 more
wiley   +1 more source