Results 101 to 110 of about 12,217,563 (347)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

PWP1 is overexpressed in hepatocellular carcinoma and facilitates liver cancer cell proliferation

Heliyon
Identification of novel biomarkers for prediction of disease course and prognosis is needed to reduce morbidity of liver hepatocellular carcinoma (LIHC/HCC) patients.
Rong Huang, Fu Xu, Luying Su, Yan Lu, Wei Liu, Shuaihu Liu, Ling Yang, Liya Su, Wei Song   +8 more
doaj   +1 more source

Effect of ergothioneine on tissue metabolism in middle-aged and aged mice [PDF]

Jichu yixue yu linchuang
Objective To investigate the effect of ergothioneine(EGT) on tissue metabolism in middle-aged and aged mice. Methods Nine-month-old middle-aged and aged C57BL/6J mice were selected to be gavaged with EGT aqueous solution at the dose and frequency of 35 ...
CHEN Haoran, WANG Fang, MA Yanni, YU Jia, WANG Lin
doaj   +1 more source

Selection pressure and organizational cognition: implications for the social determinants of health [PDF]

, 2001
We model the effects of Schumperterian 'selecton pressures' -- in particular Apartheid and the neoliberal 'market economy' -- on organizational cognition in minority communities, given the special role of culture in human biology.
Wallace, Rodrick
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Proteome and ubiquitinome analyses of the brain cortex in K18-hACE2 mice infected with SARS-CoV-2

iScience
Summary: Clinical research indicates that SARS-CoV-2 infection is linked to several neurological consequences, and the virus is still spreading despite the availability of vaccinations and antiviral medications. To determine how hosts respond to SARS-CoV-
Qiaochu Wang, Wanjun Peng, Yehong Yang, Yue Wu, Rong Han, Tao Ding, Xutong Zhang, Jiangning Liu, Juntao Yang, Jiangfeng Liu   +9 more
doaj   +1 more source

Universal scaling relation in high-temperature superconductors

, 2004
Scaling laws express a systematic and universal simplicity among complex systems in nature. For example, such laws are of enormous significance in biology. Scaling relations are also important in the physical sciences.
A Pimenov, AV Pronin, AV Puchkov, C Niedermayer, C. C. Homes, CC Homes, CC Homes, CC Homes, D. A. Bonn, D. N. Basov, DB Tanner, DN Basov, DN Basov, DN Basov, EJ Singley, G. Yu, H Eisaki, HL Liu, J Orenstein, J Schützmann, JG Bednorz, LN Bulaevskii, M. Greven, M. Strongin, N. Kaneko, O Klein, Ruixing Liang, S Chakravarty, S. V. Dordevic, Seiki Komiya, SV Dordevic, T Shibauchi, T Startseva, T. Timusk, V Ambegaokar, W. N. Hardy, WE Lawrence, WN Hardy, X. Zhao, Y Ando, YJ Uemura, Yoichi Ando, Z-X Shen   +42 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Discovery of Zharp1-163 as a dual inhibitor of ferroptosis and necroptosis for the treatment of inflammatory disorders and kidney injury

Cell Death Discovery
Dysregulation of cell death plays a critical role in the onset and progression of numerous human diseases. Distinct forms of regulated cell death, such as necroptosis and ferroptosis, have been implicated in the pathogenesis of various conditions ...
Yuting Ji, Shujing Du, Jingjing Li, Haikuo Ma, Xinhui Wang, Yongjin Hao, Zhanhui Li, Haohao Lu, Hao Liu, Chengkui Yang, Xiaohu Zhang, Sudan He   +11 more
doaj   +1 more source

Effects of intraperitoneal injection of busulfan on metabolic characteristics of spermatogonial stem cells [PDF]

Jichu yixue yu linchuang
Objective To establish a mouse model treated with busulfan and to investigate its effects on the metabolism of spermatogonial stem cells (SSCs) of mouse testis.
YU Zhixin, MANG Xinyu, ZOU Dingfeng, MIAO Shiying, SONG Wei, LI Kai
doaj   +1 more source