Results 101 to 110 of about 2,572,200 (301)

LncRNA Snhg3 aggravates hepatic steatosis via PPARγ signaling

eLife
LncRNAs are involved in modulating the individual risk and the severity of progression in metabolic dysfunction-associated fatty liver disease (MASLD), but their precise roles remain largely unknown.
Xianghong Xie, Mingyue Gao, Wei Zhao, Chunmei Li, Weihong Zhang, Jiahui Yang, Yinliang Zhang, Enhui Chen, Yanfang Guo, Zeyu Guo, Minglong Zhang, Ebenezeri Erasto Ngowi, Heping Wang, Xiaoman Wang, Yinghan Zhu, Yiting Wang, Xiaolu Li, Hong Yao, Li Yan, Fude Fang, Meixia Li, Aijun Qiao, Xiaojun Liu   +22 more
doaj   +1 more source

HJT-sRNA-m7 bencaosome modulates fibrosis progression in a silicosis mouse model [PDF]

Jichu yixue yu linchuang
Objective To explore the role and mechanism of HJT-sRNA-m7 (M7) bencaosome in a silicosis mouse model. Methods C57BL/6J mice were randomly divided into four groups: blank, control, negative control (NC) oligonucleotide, and M7 treatment (HJT-sRNA-m7 ...
CHANG Jiahui, REN Pengju, ZHOU Yunyi, JIANG Chengyu, ZHANG Yanli
doaj   +1 more source

Mechanical and Systems Biology of Cancer

Computational and Structural Biotechnology Journal, 2018
18 pages, 3 ...
Fabian Spill, Chris Bakal, Michael Mak
openaire   +5 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Integrating network pharmacology, molecular docking and experimental verification to explore the protective effect of Buyang Huanwu Decoction on cerebral ischemic stroke

Results in Chemistry
Cerebral ischemic stroke (CIS), the most prevalent form of stroke worldwide, exerts substantial impacts on both public health and socioeconomic conditions, particularly among elderly populations.
Yixuan Guo, Wenqian Liu, Bingsen Qi, Ziyi Liu, Jiaxin Wang, Le Yang, Jingcun Sun, Jinlong Qi   +7 more
doaj   +1 more source

Study of dynamic transcriptome during mitosis of HAP1 cells [PDF]

Jichu yixue yu linchuang
Objective To comprehensively understand the map of transcripts during mitosis and their regulatory mechanisms of HAP1 cells by conducting transcriptome sequencing analysis after being released by mitotic synchronization arrest.
WU Xueli, YANG Yurong, BAO Yongli, WU Rucheng, WANG Lisha, CHEN Yang
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Heat-induced denaturation of cataract-related human γD-crystallin [PDF]

Jichu yixue yu linchuang
Objective To reveal the thermally induced denaturation of wild-type human γD-crystallin(HGD) and congenital cataract-related mutant (HGD P23T), and compare the differences in the structural changes between wild-type and mutants during a heating process.
ZHOU Xin, LI Zhenyan, LI Shuyuan, ZHANG Wenbo, WANG Chenxuan
doaj   +1 more source

Design and construction of a new Drosophila species, D.synthetica, by synthetic regulatory evolution [PDF]

, 2011
Here, I merge the principles of synthetic biology^1,2^ and regulatory evolution^3-11^ to create a new species^12-15^ with a minimal set of known elements.
Eduardo Moreno
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source