Results 111 to 120 of about 12,217,563 (347)
Computational modeling to elucidate molecular mechanisms of epigenetic memory
, 2015 How do mammalian cells that share the same genome exist in notably distinct phenotypes, exhibiting differences in morphology, gene expression patterns, and epigenetic chromatin statuses?
Alsing +68 more
core +1 more source
Systems biology of cisplatin resistance: past, present and future
Cell Death and Disease, 2014 The platinum derivative cis-diamminedichloroplatinum(II), best known as cisplatin, is currently employed for the clinical management of patients affected by testicular, ovarian, head and neck, colorectal, bladder and lung cancers.
L. Galluzzi +7 more
semanticscholar +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Advanced ScienceThe development of the mammalian neocortex is precisely regulated by temporal gene expression, yet the temporal regulatory mechanisms of cortical neurogenesis, particularly how radial glial cells (RGCs) sequentially generate deep to superficial neurons ...
Jiarui Wu +8 more
doaj +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Atypical β-strand insertion mediates the noncovalent cross-linking in amyloid aggregates
Nature Communicationsβ-Strand motifs are essential recognition modules in protein-protein interactions (PPIs), which govern cellular signaling networks and regulate molecular pathway dynamics. Herein we present an unexpected discovery of a previously uncharacterized β-strand
Shanshan Mo +11 more
doaj +1 more source
Network pharmacology-based screening and validation of tea-derived small molecules against lung cancer [PDF]
Jichu yixue yu linchuangObjective To screen the active chemical components with potential therapeutic effects against lung cancer in tea and to provide new insights into the treatment and prevention of lung cancer.
YANG Rui, DU Sifen, JIANG Lehui, FU Tian, REN Pengju, JIANG Chengyu, ZHANG Yanli
doaj +1 more source
Design and construction of a new Drosophila species, D.synthetica, by synthetic regulatory evolution [PDF]
, 2011 Here, I merge the principles of synthetic biology^1,2^ and regulatory evolution^3-11^ to create a new species^12-15^ with a minimal set of known elements.
Eduardo Moreno
core +1 more source
The Potential of Systems Biology to Discover Antibacterial Mechanisms of Plant Phenolics
Frontiers in Microbiology, 2017 Drug resistance of bacterial pathogens is a growing problem that can be addressed through the discovery of compounds with novel mechanisms of antibacterial activity. Natural products, including plant phenolic compounds, are one source of diverse chemical
F. Nazzaro +8 more
semanticscholar +1 more source
Mechanical and Systems Biology of Cancer
Computational and Structural Biotechnology Journal, 2018 18 pages, 3 ...
Fabian Spill, Chris Bakal, Michael Mak
openaire +5 more sources