Increasing ambient temperature progressively disassembles Arabidopsis phytochrome B from individual photobodies with distinct thermostabilities. [PDF]
, 2020 Warm temperature is postulated to induce plant thermomorphogenesis through a signaling mechanism similar to shade, as both destabilize the active form of the photoreceptor and thermosensor phytochrome B (phyB).
Chen, Meng +3 more
core
Ferroptosis interaction with inflammatory microenvironments: Mechanism, biology, and treatment.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022 Jing Dou +4 more
semanticscholar +1 more source
Immunoregulatory mechanisms of the arachidonic acid pathway in cancer
FEBS Letters, EarlyView.The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine +3 more
wiley +1 more source
Frontiers in PharmacologyIntroduction: The transmembrane channel-like (TMC) protein family contains eight members, TMC1–TMC8. Among these members, only TMC1 and TMC2 have been intensively studied. They are expressed in cochlear hair cells and are crucial for auditory sensations.
Yating An +12 more
doaj +1 more source
The challenges of purely mechanistic models in biology and the minimum need for a 'mechanism-plus-X' framework [PDF]
arXiv, 2019 Ever since the advent of molecular biology in the 1970s, mechanical models have become the dogma in the field, where a "true" understanding of any subject is equated to a mechanistic description. This has been to the detriment of the biomedical sciences, where, barring some exceptions, notable new feats of understanding have arguably not been achieved ...
arxiv
Landauer in the age of synthetic biology: energy consumption and information processing in biochemical networks [PDF]
, 2015 A central goal of synthetic biology is to design sophisticated synthetic cellular circuits that can perform complex computations and information processing tasks in response to specific inputs. The tremendous advances in our ability to understand and manipulate cellular information processing networks raises several fundamental physics questions: How ...
arxiv +1 more source
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
LncRNA Snhg3 aggravates hepatic steatosis via PPARγ signaling
eLifeLncRNAs are involved in modulating the individual risk and the severity of progression in metabolic dysfunction-associated fatty liver disease (MASLD), but their precise roles remain largely unknown.
Xianghong Xie +22 more
doaj +1 more source
What can biology bestow to quantum mechanics? [PDF]
arXiv, 2000 The biological hierarchy and the differences between living and non-living matter are considered from the standpoint of quantum mechanics.
arxiv
The biology and mechanism of action of suppressor of cytokine signaling 3
Growth Factors, 2012 Suppressors of cytokine signaling 3 (SOCS3) has been shown to be an important and non-redundant feedback inhibitor of several cytokines including leukemia inhibitory factor, IL-6, IL-11, Ciliary neurotrophic factor (CNTF), leptin, and granulocyte colony ...
J. Babon, N. Nicola
semanticscholar +1 more source