Results 11 to 20 of about 12,217,563 (347)

αKG-driven RNA polymerase II transcription of cyclin D1 licenses malic enzyme 2 to promote cell-cycle progression

Cell Reports, 2023
Summary: Increased metabolic activity usually provides energy and nutrients for biomass synthesis and is indispensable for the progression of the cell cycle.
Yanting Yang, Zhenxi Zhang, Wei Li, Yufan Si, Li Li, Wenjing Du   +5 more
doaj   +1 more source

Transcriptional analysis and target genes discovery of Pseudomonas aeruginosa biofilm developed ex vivo chronic wound model

AMB Express, 2021
Bacterial biofilms formation is one of the major reasons for treatment failure in chronic wound infections. Therefore, diagnostic biomarkers remain the best option for prevention and treatment of chronic wound infections by biofilms.
Xiaojuan Tan, Xi Cheng, Mei Hu, Yifan Zhang, Aiqun Jia, Jinwei Zhou, Guoping Zhu   +6 more
doaj   +1 more source

In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation

Genome Biology, 2023
Background Harnessing hepatocytes for basic research and regenerative medicine demands a complete understanding of the genetic determinants underlying hepatocyte differentiation and maturation.
Junbo Liang, Jinsong Wei, Jun Cao, Jun Qian, Ran Gao, Xiaoyu Li, Dingding Wang, Yani Gu, Lei Dong, Jia Yu, Bing Zhao, Xiaoyue Wang   +11 more
doaj   +1 more source

Homeostasis as the Mechanism of Evolution. [PDF]

, 2015
Homeostasis is conventionally thought of merely as a synchronic (same time) servo-mechanism that maintains the status quo for organismal physiology. However, when seen from the perspective of developmental physiology, homeostasis is a robust, dynamic ...
Torday, John S
core   +2 more sources

Epigenetics: Biology's Quantum Mechanics [PDF]

Frontiers in Plant Science, 2011
The perspective presented here is that modern genetics is at a similar stage of development as were early formulations of quantum mechanics theory in the 1920s and that in 2010 we are at the dawn of a new revolution in genetics that promises to enrich and deepen our understanding of the gene and the genome. The interrelationships and interdependence of
openaire   +3 more sources

Proteomic and functional profiling of platelet-derived extracellular vesicles released under physiological or tumor-associated conditions

Cell Death Discovery, 2022
During hemostasis, thrombosis, and inflammation, activated blood platelets release extracellular vesicles (PEVs) that represent biological mediators of physiological and pathological processes.
Mauro Vismara, Marcello Manfredi, Marta Zarà, Silvia Maria Grazia Trivigno, Luca Galgano, Silvia Stella Barbieri, Ilaria Canobbio, Mauro Torti, Gianni Francesco Guidetti   +8 more
doaj   +1 more source

Towards molecular systems biology of gene transcription and regulation [PDF]

, 2010
Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Cramer, Patrick
core   +1 more source

Toward Mechanical Systems Biology in Bone [PDF]

Annals of Biomedical Engineering, 2012
ISSN:1573 ...
Trüssel, Andreas, Müller, Ralph, Webster, Duncan   +2 more
openaire   +3 more sources

Making serine integrases work for us [PDF]

, 2017
DNA site-specific recombinases are enzymes (often associated with mobile DNA elements) that catalyse breaking and rejoining of DNA strands at specific points, thereby bringing about precise genetic rearrangements.
Stark, W. Marshall
core   +1 more source

Osteoarthritis year in review 2021: biology.

Osteoarthritis and Cartilage, 2021
This year in review on osteoarthritis biology summarizes a series of research articles published between the 2020 and 2021 Osteoarthritis Research Society International (OARSI) World Congress. Research hightlights were selected and discussed based on the
Yangzi Jiang
semanticscholar   +1 more source