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LAG3’s Enigmatic Mechanism of Action
LAG3 is an important immune checkpoint with relevance in cancer, infectious disease and autoimmunity. However, despite LAG3’s role in immune exhaustion and the great potential of LAG3 inhibition as treatment, much remains unknown about its biology ...
Colin G Graydon, S. Mohideen, K. Fowke
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A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification
Platelet-rich plasma (PRP) is currently used in different medical fields. The interest in the application of PRP in dermatology has recently increased.
Rubina Alves, R. Grimalt
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Mechanism of Action and Biology of Flow Diverters in the Treatment of Intracranial Aneurysms.
Flow diverters have drastically changed the landscape of intracranial aneurysm treatment and are now considered first-line therapy for select lesions. Their mechanism of action relies on intrinsic alteration in hemodynamic parameters, both at the parent ...
K. Ravindran+5 more
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Ferroptosis: Emerging mechanisms, biology and hallmarks
: Ferroptosis is a new type of cell death which is iron-dependent and caused by lipid peroxidation, distinguished from apoptosis, necrosis, pyroptosis, and autophagy.
Zixun Wang, Daowei Li
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Carl F. Craver and Lindley Darden: \u3cem\u3eIn Search of Mechanisms: Discoveries Across the Life Sciences\u3c/em\u3e [PDF]
Carl Craver and Lindley Darden are two of the foremost proponents of a recent approach to the philosophy of biology that is often called the New Mechanism.
Glennan, Stuart
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Type II-C CRISPR-Cas9 Biology, Mechanism, and Application.
Genome editing technologies have been revolutionized by the discovery of prokaryotic RNA-guided defense system called CRISPR-Cas. Cas9, a single effector protein found in type II CRISPR systems, has been at the heart of this genome editing revolution ...
Aamir Mir+3 more
semanticscholar +1 more source
Making serine integrases work for us [PDF]
DNA site-specific recombinases are enzymes (often associated with mobile DNA elements) that catalyse breaking and rejoining of DNA strands at specific points, thereby bringing about precise genetic rearrangements.
Stark, W. Marshall
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Environmental epigenetics and climate change [PDF]
Epigenetics co-evolved with deoxyribonucleic acid sequence as the molecular mechanism to regulate gene expression and chromatin structure and provide the conduit for the environment to influence biology and evolution.
Skinner, Michael K.
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MicroRNAs: From Mechanism to Organism
MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors of gene expression in diverse biological contexts. The emergence of small RNA-mediated gene silencing preceded the onset of multicellularity and was followed by a ...
Philip Dexheimer, L. Cochella
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