Results 21 to 30 of about 10,501,738 (419)

LAG3’s Enigmatic Mechanism of Action

open access: yesFrontiers in Immunology, 2021
LAG3 is an important immune checkpoint with relevance in cancer, infectious disease and autoimmunity. However, despite LAG3’s role in immune exhaustion and the great potential of LAG3 inhibition as treatment, much remains unknown about its biology ...
Colin G Graydon, S. Mohideen, K. Fowke
semanticscholar   +1 more source

A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification

open access: yesSkin Appendage Disorders, 2017
Platelet-rich plasma (PRP) is currently used in different medical fields. The interest in the application of PRP in dermatology has recently increased.
Rubina Alves, R. Grimalt
semanticscholar   +1 more source

Mechanism of Action and Biology of Flow Diverters in the Treatment of Intracranial Aneurysms.

open access: yesNeurosurgery, 2019
Flow diverters have drastically changed the landscape of intracranial aneurysm treatment and are now considered first-line therapy for select lesions. Their mechanism of action relies on intrinsic alteration in hemodynamic parameters, both at the parent ...
K. Ravindran   +5 more
semanticscholar   +1 more source

Ferroptosis: Emerging mechanisms, biology and hallmarks

open access: yesMEDS Clinical Medicine, 2023
: Ferroptosis is a new type of cell death which is iron-dependent and caused by lipid peroxidation, distinguished from apoptosis, necrosis, pyroptosis, and autophagy.
Zixun Wang, Daowei Li
semanticscholar   +1 more source

Carl F. Craver and Lindley Darden: \u3cem\u3eIn Search of Mechanisms: Discoveries Across the Life Sciences\u3c/em\u3e [PDF]

open access: yes, 2014
Carl Craver and Lindley Darden are two of the foremost proponents of a recent approach to the philosophy of biology that is often called the New Mechanism.
Glennan, Stuart
core   +2 more sources

Type II-C CRISPR-Cas9 Biology, Mechanism, and Application.

open access: yesACS Chemical Biology, 2017
Genome editing technologies have been revolutionized by the discovery of prokaryotic RNA-guided defense system called CRISPR-Cas. Cas9, a single effector protein found in type II CRISPR systems, has been at the heart of this genome editing revolution ...
Aamir Mir   +3 more
semanticscholar   +1 more source

Making serine integrases work for us [PDF]

open access: yes, 2017
DNA site-specific recombinases are enzymes (often associated with mobile DNA elements) that catalyse breaking and rejoining of DNA strands at specific points, thereby bringing about precise genetic rearrangements.
Stark, W. Marshall
core   +1 more source

Environmental epigenetics and climate change [PDF]

open access: yes, 2022
Epigenetics co-evolved with deoxyribonucleic acid sequence as the molecular mechanism to regulate gene expression and chromatin structure and provide the conduit for the environment to influence biology and evolution.
Skinner, Michael K.
core   +2 more sources

MicroRNAs: From Mechanism to Organism

open access: yesFrontiers in Cell and Developmental Biology, 2020
MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors of gene expression in diverse biological contexts. The emergence of small RNA-mediated gene silencing preceded the onset of multicellularity and was followed by a ...
Philip Dexheimer, L. Cochella
semanticscholar   +1 more source

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