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Molecular mechanisms of telomere biology disorders [PDF]
Journal of Biological Chemistry, 2021 Genetic mutations that affect telomerase function or telomere maintenance result in a variety of diseases collectively called telomeropathies. This wide spectrum of disorders, which include dyskeratosis congenita, pulmonary fibrosis, and aplastic anemia, is characterized by severely short telomeres, often resulting in hematopoietic stem cell failure in
Sherilyn Grill, Jayakrishnan Nandakumar
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Carl F. Craver and Lindley Darden: \u3cem\u3eIn Search of Mechanisms: Discoveries Across the Life Sciences\u3c/em\u3e [PDF]
, 2014 Carl Craver and Lindley Darden are two of the foremost proponents of a recent approach to the philosophy of biology that is often called the New Mechanism.
Glennan, Stuart
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Steering proton migration in hydrocarbons using intense few-cycle laser fields [PDF]
, 2016 Proton migration is a ubiquitous process in chemical reactions related to biology, combustion, and catalysis. Thus, the ability to control the movement of nuclei with tailored light, within a hydrocarbon molecule holds promise for far-reaching ...
Alnaser, A. S. +12 more
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A clickable oxysterol photolabel retains NMDA receptor activity and accumulates in neurons [PDF]
, 2018 Oxysterol analogs that modulate NMDA receptor function are candidates for therapeutic development to treat neuropsychiatric disorders. However, the cellular actions of these compounds are still unclear.
Benz, Ann +6 more
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Ferroptosis: mechanisms, biology and role in disease
Nature Reviews Molecular Cell Biology, 2021 The research field of ferroptosis has seen exponential growth over the past few years, since the term was coined in 2012. This unique modality of cell death, driven by iron-dependent phospholipid peroxidation, is regulated by multiple cellular metabolic pathways, including redox homeostasis, iron handling, mitochondrial activity and metabolism of amino
Xuejun Jiang +2 more
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Nature Communications, 2020 Water intake is critical to our life, and the subfornical organ in the brain involved in the control of this behavior. Here, the authors reveal that two distinct groups of CCK-producing neurons in the SFO suppress water intake according to the ...
Takashi Matsuda +4 more
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Circulating markers of ageing and allostatic load: a slow train coming [PDF]
, 2017 Dealing with the growing burden of age-related morbidities is one of the greatest challenges facing modern society. How we age across the lifecourse and how psychosocial and lifestyle factors interplay with the biology of ageing remains to be fully ...
Kooman, Jeroen P. +3 more
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Nature Communications, 2020 Fukutin-related protein (FKRP) catalyses the addition of ribitol-phosphate (RboP) to the O-mannosyl glycan of α-dystroglycan and mutations in FKRP cause dystroglycanopathy. Here the authors provide insights into its oligomerization and recognition of the
Naoyuki Kuwabara +11 more
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Is synthetic biology mechanical biology?
History and Philosophy of the Life Sciences, 2015 A widespread and influential characterization of synthetic biology emphasizes that synthetic biology is the application of engineering principles to living systems. Furthermore, there is a strong tendency to express the engineering approach to organisms in terms of what seems to be an ontological claim: organisms are machines.
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Toward Mechanical Systems Biology in Bone [PDF]
Annals of Biomedical Engineering, 2012 ISSN:1573 ...
Trüssel, Andreas +2 more
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