Results 91 to 100 of about 3,894,411 (305)

Investigating the Mechanism of Action of Schisandra chinensis Combined with Coenzyme Q10 in the Treatment of Heart Failure Based on PI3K-AKT Pathway

Drug Design, Development and Therapy, 2023
Sihua Wen,1,* Kai Yang,1,* Yunfeng Bai,2 Yanan Wu,1 Ding Liu,1 Xu Wu,1 Xiaofei Zhang,1 Jing Sun1 1Department of Pharmaceutics, The Key Laboratory of Basic and New Drug Research of Traditional Chinese Medicine, Shaanxi University of Chinese ...
Wen S, Yang K, Bai Y, Wu Y, Liu D, Wu X, Zhang X, Sun J   +7 more
doaj  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Universal Features of Holographic Anomalies

, 2003
We study the mechanism by which gravitational actions reproduce the trace anomalies of the holographically related conformal field theories. Two universal features emerge: a) the ratios of type B trace anomalies in any even dimension are independent of ...
A. Schwimmer, Adam Schwimmer, C. Fefferman, C. Imbimbo, E. Witten, G. Arutyunov, J. de Boer, J. Erdmenger, J. Kalkkinen, J.D. Brown, K. Skenderis, M. Abramowitz, M. Bianchi, M. Bianchi, M. Blau, M. Henningson, M.J. Duff, O. Aharony, R.Penrose, S. de Haro, S. Deser, S. Nojiri, S. Theisen, S.A. Fulling, Stefan Theisen   +24 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Biologically Active Nonribosomal Peptides.I. Nonribosamal Polypeptide Antibiotics

Антибиотики и Химиотерапия, 2020
The data on novel polypeptide antibiotics described within the last 10-15 years, as well as new researches on the known antibiotics with respect to their mechanisms of action and microbial resistance are presented.
T. I. Orlova, V. G. Bulgakova, A. N. Polin   +2 more
doaj  

Mechanism of Anticonvulsant Action of ACTH

Pediatric Neurology Briefs, 2001
The hypothesis that systemic or intraventricular administration of corticotropin (ACTH) acts directly on limbic neurons to modulate corticotropin-releasing hormone (CRH) gene expression, independently of adrenal stimulation, was tested and confirmed in ...
J Gordon Millichap
doaj   +1 more source

Rituximab: Mechanism of Action [PDF]

Seminars in Hematology, 2010
Rituximab is a mainstay in the therapy for a broad variety of B-cell malignancies. Despite its undeniable therapeutic value, we still do not fully understand the mechanisms of action responsible for rituximab's anti-tumor effects. Direct signaling, complement-mediated cytotoxicity (CMC), and antibody-dependent cellular cytotoxicity (ADCC) all appear to
openaire   +2 more sources

Mechanism of action of VP1-001 in cryAB(R120G)-associated and age-related cataracts [PDF]

, 2019
PurposeWe previously identified an oxysterol, VP1-001 (also known as compound 29), that partially restores the transparency of lenses with cataracts. To understand the mechanism of VP1-001, we tested the ability of its enantiomer, ent-VP1-001, to bind ...
Andley, Usha P., Covey, Douglas F., Dunyak, Bryan M., Gestwicki, Jason E., Hamilton, Paul D., Izrayelit, Yevgeniy, Makley, Leah N., McGlasson-Naumann, Brittney, Molnar, Kathleen S., Qian, Mingxing, Su, Bonnie   +10 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Does the Size of the Action Set Matter for Coorperation [PDF]

We use the voluntary contribution mechanism to investigate whether smaller action sets lead to higher cooperation rates. We ?nd that this is the case for groups of four players.action set; voluntary contribution mechanism; prisoner?s ...
Lata Gangadharan, Nikos Nikiforakis
core