Results 141 to 150 of about 4,146,035 (404)

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

Appearence of Mother Universe and Singular Vertices in Random Geometries

open access: yes, 1996
We discuss a general mechanism that drives the phase transition in the canonical ensemble in models of random geometries. As an example we consider a solvable model of branched polymers where the transition leading from tree- to bush-like polymers relies
Agishtein   +18 more
core   +3 more sources

Review of the Mechanisms of Caffeine Effect on Skin and Hair Health

open access: yesمجله دانشکده پزشکی اصفهان, 2016
Caffeine -a methylxanthine derived from purine- is found in the various plants (coffee, tea, cola) all over the world and is widely used in cosmetics due to its ability to penetrate in skin barriers.
Hanieh Sharifian-Koupaiee   +3 more
doaj  

The Antibacterial Activity and Mechanism of Action of Luteolin Against Trueperella pyogenes

open access: yesInfection and Drug Resistance, 2020
Yuru Guo,1 Yan Liu,2 Zehui Zhang,1 Menghan Chen,1 Dexian Zhang,1 Chunlian Tian,1 Mingchun Liu,1 Guotuo Jiang2 1Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, College of Animal Science and Veterinary Medicine ...
Guo Y   +7 more
doaj  

The Mechanism of Action of Lysobactin.

open access: yesJournal of the American Chemical Society, 2016
Lysobactin, also known as katanosin B, is a potent antibiotic with in vivo efficacy against Staphylococcus aureus and Streptococcus pneumoniae. It was previously shown to inhibit peptidoglycan (PG) biosynthesis, but its molecular mechanism of action has ...
Wonsik Lee   +7 more
semanticscholar   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

FURTHER OBSERVATIONS ON THE MECHANISM OF PHAGE ACTION [PDF]

open access: bronze, 1946
A. P. Krueger   +2 more
openalex   +1 more source

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

open access: yesFEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos   +3 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

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