Results 271 to 280 of about 4,146,035 (404)

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Exploring miR-301a-3p and osteosarcoma: from expression differences to mechanism of action. [PDF]

Discov Oncol
Liu T, Ma M.
europepmc   +1 more source

ON THE MECHANISM OF COCARBOXYLASE ACTION; A REINVESTIGATION

, 1940
Kurt G. Stern, Joseph L. Melnick
openalex   +1 more source

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

Molecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul, François Guillonneau, Odile Blanchet, Hamza Lasla, Audrey Rousseau, Catherine Guette, Alice Boissard, Cécile Henry, Morgan Dhondt, Pascal Jézéquel, Philippe Menei, Jean‐Michel Lemée   +11 more
wiley   +1 more source

Cross modality learning of cell painting and transcriptomics data improves mechanism of action clustering and bioactivity modelling. [PDF]

Sci Rep
Ha SV, Jaensch S, Kańduła MM, Herman D, Czodrowski P, Ceulemans H.   +5 more
europepmc   +1 more source

Unique features of trabectedin mechanism of action

Cancer Chemotherapy and Pharmacology, 2016
A. Larsen, C. Galmarini, M. D’Incalci
semanticscholar   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Elucidation of Mechanism of Action in Drug Invention: Using Stable Isotope Tracers to Unravel Biochemical Kinetics. [PDF]

Pharmacol Res Perspect
Kohnz RA, Zhou D, Lou B, Yao H, McKenney D, Dokwal D, Villanueva R, Kocalis H, Ballard JE, Piesvaux J, Previs SF.   +10 more
europepmc   +1 more source

Mechanism of the Toxic Action of Germicides on Whole Blood Measured by the Loss of Phagocytic Activity of Leucocytes

, 1939
Henry Welch
openalex   +1 more source

MECHANISM OF ACTION OF PENICILLIN [PDF]

Journal of Bacteriology, 1957
openaire   +3 more sources