Results 281 to 290 of about 4,146,035 (404)

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Amphetamine use and Parkinson's disease: integration of artificial intelligence prediction, clinical corroboration, and mechanism of action analyses. [PDF]

PLoS One
Gorenflo MP, Gao Z, Davis PB, Kaelber D, Xu R.   +4 more
europepmc   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Mechanism of Action of Formate Dehydrogenases. [PDF]

J Am Chem Soc
Niks D, Hakopian S, Canchola A, Lin YH, Hille R.   +4 more
europepmc   +1 more source

The Mechanism of Action of the Fungicide, 2 -Heptadecyl-2-imidazoline

, 1955
Brian L. West, Frederick T. Wolf
openalex   +1 more source

Role and mechanism of action of sclerostin in bone.

Bone, 2017
J. Delgado-Calle, Amy Y. Sato, T. Bellido   +2 more
semanticscholar   +1 more source

Beyond cytotoxic T cells: reprogrammed regulatory T cells help facilitate response to dual checkpoint blockade

Molecular Oncology, EarlyView.
Rolig, Peng, and colleagues have shed new light on how dual blockade of PD1 and LAG3 enhances antitumor immunity. They found that response to immunotherapy with anti‐PD1 + anti‐LAG3 was associated with reprogramming of canonically suppressive CD4+ regulatory T cells to an inflammatory state.
Tullia C. Bruno, Anthony R. Cillo
wiley   +1 more source

Identification of a Possible Endocannabinoid-Mediated Mechanism of Action of Cetylated Fatty Acids. [PDF]

Biomolecules
Bononi G, Granchi C, Tuccinardi T, Minutolo F.   +3 more
europepmc   +1 more source

Studies on the Mechanism of the Antibiotic Action of Vitamin K-II

, 1954
Manabu Kitamikado, Shizuo MORI
openalex   +2 more sources

Antibacterial Activity and Mechanism of Action of the Silver Ion in Staphylococcus aureus and Escherichia coli

Applied and Environmental Microbiology, 2008
W. Jung, H. Koo, Ki Woo Kim, Sook Shin, So Hyun Kim, Y. Park   +5 more
semanticscholar   +1 more source