Results 281 to 290 of about 3,910,323 (355)

Mechanism of action of IHH in ameliorating thin endometrium. [PDF]

J Reprod Dev
Luo L, Luo M, Ning D, Chen X, Zheng Q, Cao Q.   +5 more
europepmc   +1 more source

Evaluating the efficacy, safety and possible mechanism of action of potassium humate with selenium

, 2014
Tsakani Locrecia Chauke
openalex   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Bioactive Plant Peptides: Physicochemical Features, Structure-Function Insights and Mechanism of Action. [PDF]

Molecules
Avilés-Gaxiola S, García-Aguiar I, Jiménez-Ortega LA, Gutiérrez-Grijalva EP, Heredia JB.   +4 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action. [PDF]

J Exp Med
Wilhelmsen K, Deshpande A, Tronnes S, Mahanta M, Banicki M, Cochran M, Cowdin S, Fortney K, Hartman G, Hughes RE, Montgomery R, Portillo CP, Rubin P, Salazar T, Wang Y, Yan S, Morgan BA, Duisembekova A, Riou R, Marleaux M, Hochheiser IV, Buthmann H, Ferber D, Torp J, Wang W, Cranston M, McKee CM, Mawhinney TJ, McKay EC, Eroglu FK, Kümmerle-Deschner J, Weber ANR, Py BF, Geyer M, Coll RC.   +34 more
europepmc   +1 more source

Contemporary insights into elamipretide's mitochondrial mechanism of action and therapeutic effects. [PDF]

Biomed Pharmacother
Sabbah HN, Alder NN, Sparagna GC, Bruce JE, Stauffer BL, Chao LH, Pitceathly RDS, Maack C, Marcinek DJ.   +8 more
europepmc   +1 more source

Vasorelaxant effects of the edible flowers <i>Tagetes erecta</i> L. and its possible mechanism of action. [PDF]

Pharm Biol
Núñez S, López V, Arruebo Loshuertos MP, Plaza Carrión MÁ, Gómez-Rincón C, Valero MS.   +5 more
europepmc   +1 more source

Mechanism of action of Butein in cutaneous squamous cell carcinoma through regulation of the TWEAK-FN14 signaling pathway. [PDF]

Front Oncol
Dong Q, Zhang Z, Li S, Wang X, Zhang H, Bai J, Zheng K, Liang L.   +7 more
europepmc   +1 more source

Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis. [PDF]

Nat Commun
Bond AN, Orzechowski M, Zhang S, Ben-Zion I, Lemmer A, Garry N, Lee K, Chen M, Delano K, Gath E, Golas AL, Nietupski R, Fitzgerald M, Ehrt S, Rubin EJ, Sassetti CM, Schnappinger D, Shoresh N, Hunt DK, Gomez JE, Hung DT.   +20 more
europepmc   +1 more source