Results 81 to 90 of about 4,146,035 (404)

Metformin: update on mechanisms of action and repurposing potential

Nature Reviews Endocrinology, 2023
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in most guidelines and is used daily by >200 million patients.
M. Foretz, B. Guigas, B. Viollet
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Mass Transfer Mechanism in Real Crystals by Pulsed Laser Irradiation

, 2002
The dynamic processes in the surface layers of metals subjected activity of a pulsing laser irradiation, which destroyed not the crystalline structure in details surveyed.
A. E. Pogorelov, A. F. Zhuravlyov, Apollonov V. V., Bondarenko G. G., Danilovskaya V. I., Gordeev V. F., Gurevich M. E., Gurevich M. E., Gurevich M. E., Gurevich M. E., Gurevich M. E., Gurevich M. E., K. P. Ryaboshapka, Krishtal M. A., Krishtal M. A., Larikov L. N., Pogorelov A. E., Volosevich P. Yu., Zolotukhin A. A.   +18 more
core   +1 more source

Role of micronutrients and natural antioxidants in fighting against HIV; a quick mini-review [PDF]

Research Journal of Pharmacognosy, 2014
Oxidative stress has been implicated in the progression of HIV to AIDS, since HIV usually replicates in a highly oxidized condition and CD4+ T lymphocytes can be activated via a cascade of internal oxidative pathways, which enhances the formation of ...
S. Saeidnia, M. Abdollahi
doaj  

Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?

Pharmacology Research & Perspectives, 2021
The precise mechanistic action of acetaminophen (ACT; paracetamol) remains debated. ACT’s analgesic and antipyretic actions are attributed to cyclooxygenase (COX) inhibition preventing prostaglandin (PG) synthesis.
Christopher J. Esh, Bryna C. R. Chrismas, Alexis R. Mauger, Lee Taylor   +3 more
doaj   +1 more source

Correlating chemical sensitivity and basal gene expression reveals mechanism of action

Nature Chemical Biology, 2015
Changes in cellular gene expression in response to small-molecule or genetic perturbations have yielded signatures that can connect unknown mechanisms of action (MoA) to ones previously established. We hypothesized that differential basal gene expression
M. Rees, B. Seashore-Ludlow, B. Seashore-Ludlow, J. Cheah, J. Cheah, Drew J. Adams, Drew J. Adams, Edmund V. Price, Edmund V. Price, S. Gill, Sarah Javaid, Matthew E Coletti, Victor Jones, Nicole E. Bodycombe, Nicole E. Bodycombe, Christian K Soule, Christian K Soule, B. Alexander, A. Li, Philip Montgomery, J. Kotz, C. Hon, B. Muñoz, T. Liefeld, T. Liefeld, V. Dancík, D. Haber, C. Clish, Joshua A. Bittker, M. Palmer, M. Palmer, B. Wagner, P. Clemons, Alykhan F. Shamji, S. Schreiber   +34 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.

Physiological Research, 2001
Alloxan and streptozotocin are widely used to induce experimental diabetes in animals. The mechanism of their action in B cells of the pancreas has been intensively investigated and now is quite well understood.
T. Szkudelski
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Dietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of action [PDF]

, 2010
Background Patterns of food intake and prevalent osteoarthritis of the hand, hip, and knee were studied using the twin design to limit the effect of confounding factors. Compounds found in associated food groups were further studied in vitro.
AD Rowan, Aedin Cassidy, AJ MacGregor, Alex J MacGregor, AM Valdes, AS Olafsdottir, B Teucher, DA Young, DT Felson, E Brunner, E Regan, FB Hu, FB Hu, Frances MK Williams, H Amagase, H Dumond, HS Lee, Ian M Clark, JA Milner, Jane Skinner, L Sharma, MC Myzak, MD Begg, N Druesne, R Cederlof, RK Nuttall, Rose M Davidson, SA Bingham, SA Oliveria, SB Abramson, T Andrew, TD Spector, TE Cawston, TE McAlindon, TE McAlindon, TH Chen, Tim D Spector, W Willett, Y Henrotin, Y Henrotin   +39 more
core   +3 more sources