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Mechanistic Models of Virus–Bacteria Co-Infections in Humans: A Systematic Review of Methods and Assumptions [PDF]

open access: yesPathogens
Background: Viral–bacterial co-infections can amplify disease severity through complex biological mechanisms. Mathematical models are critical tools for understanding these threats, but it is unclear how well they capture the underlying biology.
Mani Dhakal   +2 more
doaj   +2 more sources

Biodiversity Dynamics on Islands: Explicitly Accounting for Causality in Mechanistic Models

open access: yesDiversity, 2017
Island biogeography remains a popular topic in ecology and has gained renewed interest due to recent theoretical development. As experimental investigation of the theory is difficult to carry out, mechanistic simulation models provide useful alternatives.
Ludwig Leidinger   +1 more
doaj   +3 more sources

Mechanistic models project bird invasions with accuracy [PDF]

open access: yesNature Communications, 2023
Invasive species pose a major threat to biodiversity and inflict massive economic costs. Effective management of bio-invasions depends on reliable predictions of areas at risk of invasion, as they allow early invader detection and rapid responses.
Diederik Strubbe   +5 more
doaj   +2 more sources

Building and Understanding the Minimal Self

open access: yesFrontiers in Psychology, 2021
Within the methodologically diverse interdisciplinary research on the minimal self, we identify two movements with seemingly disparate research agendas – cognitive science and cognitive (developmental) robotics.
Valentin Forch, Fred H. Hamker
doaj   +1 more source

Modulating Immune Response in Viral Infection for Quantitative Forecasts of Drug Efficacy

open access: yesPharmaceutics, 2023
The antiretroviral drug, the total level of viral production, and the effectiveness of immune responses are the main topics of this review because they are all dynamically interrelated.
Bárbara Costa, Nuno Vale
doaj   +1 more source

Life-stage dependent response of the epiphytic lichen Lobaria pulmonaria to climate

open access: yesFrontiers in Forests and Global Change, 2022
Lichens are poikilohydric organisms, whose internal water content tends to reflect external humidity conditions. After drying, they can reactivate their metabolic activity through water vapor uptake or liquid water input.
Luca Di Nuzzo   +7 more
doaj   +1 more source

A Mechanistic Data-Driven Approach to Synthesize Human Mobility Considering the Spatial, Temporal, and Social Dimensions Together

open access: yesISPRS International Journal of Geo-Information, 2021
Modelling human mobility is crucial in several areas, from urban planning to epidemic modelling, traffic forecasting, and what-if analysis. Existing generative models focus mainly on reproducing the spatial and temporal dimensions of human mobility ...
Giuliano Cornacchia, Luca Pappalardo
doaj   +1 more source

A mechanistic model for minimizing pressure loss in the wellbore during drilling by considering the effects of cuttings

open access: yesFrontiers in Earth Science, 2023
Because of the existence of cuttings in the flow, the pressure loss in the wellbore can increase significantly. Minimization of the flow pressure loss greatly benefits the drilling process.
Baixue Li   +11 more
doaj   +1 more source

Summary results of the 2014-2015 DARPA Chikungunya challenge

open access: yesBMC Infectious Diseases, 2018
Background: Emerging pathogens such as Zika, chikungunya, Ebola, and dengue viruses are serious threats to national and global health security. Accurate forecasts of emerging epidemics and their severity are critical to minimizing subsequent mortality ...
Sara Y. Del Valle   +14 more
doaj   +1 more source

Mechanistic Models of Signaling Pathways Reveal the Drug Action Mechanisms behind Gender-Specific Gene Expression for Cancer Treatments

open access: yesCells, 2020
Despite the existence of differences in gene expression across numerous genes between males and females having been known for a long time, these have been mostly ignored in many studies, including drug development and its therapeutic use.
Cankut Çubuk   +3 more
doaj   +1 more source

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