Results 21 to 30 of about 869,043 (286)

A Generalized Mechanistic Codon Model [PDF]

Molecular Biology and Evolution, 2014
Models of codon evolution have attracted particular interest because of their unique capabilities to detect selection forces and their high fit when applied to sequence evolution. We described here a novel approach for modeling codon evolution, which is based on Kronecker product of matrices.
Zaheri Maryam, Dib Linda, Salamin Nicolas   +2 more
openaire   +5 more sources

BayCANN: Streamlining Bayesian Calibration With Artificial Neural Network Metamodeling

Frontiers in Physiology, 2021
Purpose: Bayesian calibration is generally superior to standard direct-search algorithms in that it estimates the full joint posterior distribution of the calibrated parameters.
Hawre Jalal, Thomas A. Trikalinos, Fernando Alarid-Escudero   +2 more
doaj   +1 more source

Protein folding disorders: Toward a basic biological paradigm [PDF]

, 2010
Mechanistic 'physics' models of protein folding fail to account for the observed spectrum of protein folding and aggregation disorders, suggesting that a more appropriately biological paradigm will be needed for understanding the etiology ...
Rodrick Wallace
core   +3 more sources

Emergent global patterns of ecosystem structure and function from a mechanistic general ecosystem model [PDF]

, 2014
Anthropogenic activities are causing widespread degradation of ecosystems worldwide, threatening the ecosystem services upon which all human life depends.
A Friedlander, A Hardisty, B Cho, B Collen, B-E Sæther, BJ McGill, C Mora, C Ward-Paige, CA Deutsch, CB Field, CD Thomas, CEL Ferreira, CH Sekercioglu, CM Duarte, CR McClain, D Griffiths, D Policansky, D Post, D Yates, Derek P. Tittensor, DG Jenkins, Drew W. Purves, DW Purves, E Jeppesen, E Macpherson, E Odum, E Siemann, EA Fulton, FS Chapin, G Krinner, GA Kaufman, GM Mace, H Cyr, H Stibor, HR Peinetti, J Cebrian, J Chase, J Gasol, J Merilä, JA Carton, JE Cohen, JH Brown, JL Frangi, JM Sunday, Jon Hutton, JP Rodríguez, JS Millar, Jörn P. W. Scharlemann, K Rose, KA Nagy, KA Schubert, KE Jones, KR Buck, L Tremblay-Boyer, LLM Fedigan, LW Oring, M Behrenfeld, M González-Suárez, Matthew J. Smith, MBJ Harfoot, ME Power, Michael B. J. Harfoot, Michel Loreau, MJ Coe, MJ Morgan, MJ Smith, MJ Vander Zanden, MK Litvak, MR Evans, MW McCoy, N Blakley, N Loeuille, NG Hairston, O Krüger, P Abrams, P Del Giorgio, PK Holland, R Alkemade, R Bustamante, R Gentile, R Meek, R Shine, R Shine, RE Ricklefs, RE Ricklefs, RJ Williams, RJ Williams, RW Sheldon, RW Wilson, S Díaz, S Fretwell, S Jain, S Jennings, S Jennings, S Meiri, S Sitch, SA Sandin, SD Pletcher, Stephen Emmott, T Newbold, T Sousa, Tim Newbold, TJ Case, TJ Webb, U Brose, V Christensen, Vassily Lyutsarev, W Sprules, X Irigoien, Y-J Shin   +109 more
core   +4 more sources

Recovery in environmental risk assessments at EFSA

EFSA Journal, 2016
EFSA performs environmental risk assessments (ERAs) for single potential stressors such as plant protection products, genetically modified organisms and feed additives and for invasive alien species that are harmful for plant health.
EFSA Scientific Committee
doaj   +1 more source

Mechanistic Models of Protein Aggregation Across Length-Scales and Time-Scales: From the Test Tube to Neurodegenerative Disease

Frontiers in Neuroscience, 2022
Through advances in the past decades, the central role of aberrant protein aggregation has been established in many neurodegenerative diseases. Crucially, however, the molecular mechanisms that underlie aggregate proliferation in the brains of affected ...
Georg Meisl, Tuomas P. J. Knowles, Tuomas P. J. Knowles, David Klenerman, David Klenerman   +4 more
doaj   +1 more source

Combining mechanistic and data-driven techniques for predictive modelling of wastewater treatment plants [PDF]

, 2020
Mechanistic models are widely used for modelling of wastewater treatment plants. However, as they are based on simplified and incomplete domain knowledge, they often lack accurate predictive capabilities.
De Baets, Bernard, De Jaegher, Bram, Nopens, Ingmar, Quaghebeur, Ward   +3 more
core  

Statistical inference in mechanistic models: time warping for improved gradient matching [PDF]

, 2017
Inference in mechanistic models of non-linear differential equations is a challenging problem in current computational statistics. Due to the high computational costs of numerically solving the differential equations in every step of an iterative ...
Filippone, Maurizio, Husmeier, Dirk, Macdonald, Benn, Niu, Mu, Rogers, Simon   +4 more
core   +1 more source

A scoping review of side-dress nitrogen recommendation systems and their perspectives in precision agriculture

Italian Journal of Agronomy, 2021
A scoping review of the relevant literature was carried out to identify the existing N recommendation systems, their temporal and geographical diffusion, and knowledge gaps. In total, 151 studies were identified and categorized.
Martina Corti, Virginia Fassa, Luca Bechini   +2 more
doaj   +1 more source

Hitting the sweet spot of complexity: Reasons why the development of new custom-tailored models is still warranted and should be encouraged in aquatic sciences

Journal of Limnology, 2021
Process-based aquatic ecosystem models are increasingly being developed and used in freshwater ecology and other aquatic sciences, as they are powerful tools to gain a mechanistic understanding of ecological processes and inform policy and decision ...
Gregorio A. López Moreira M., Marco Toffolon, Franz Hölker   +2 more
doaj   +1 more source