Results 21 to 30 of about 11,335 (213)

A mechanistic model of photosynthesis in microalgae [PDF]

Biotechnology and Bioengineering, 2002
AbstractA dynamic model of photosynthesis is developed, accounting for factors such as photoadaptation, photoinhibition, and the “flashing light effect.” The model is shown to explain the reported photosynthesis–irradiance responses observed under various conditions (constant low light, constant intense irradiance, flashing light, diurnal variation in ...
F Camacho, Rubio, F García, Camacho, J M Fernández, Sevilla, Y, Chisti, E Molina, Grima   +4 more
openaire   +2 more sources

Training deep neural density estimators to identify mechanistic models of neural dynamics

eLife, 2020
Mechanistic modeling in neuroscience aims to explain observed phenomena in terms of underlying causes. However, determining which model parameters agree with complex and stochastic neural data presents a significant challenge.
Pedro J Gonçalves, Jan-Matthis Lueckmann, Michael Deistler, Marcel Nonnenmacher, Kaan Öcal, Giacomo Bassetto, Chaitanya Chintaluri, William F Podlaski, Sara A Haddad, Tim P Vogels, David S Greenberg, Jakob H Macke   +11 more
doaj   +1 more source

Predictive ability of a process‐based versus a correlative species distribution model

Ecology and Evolution, 2020
Species distribution modeling is a widely used tool in many branches of ecology and evolution. Evaluations of the transferability of species distribution models—their ability to predict the distribution of species in independent data domains—are, however,
Steven I. Higgins, Matthew J. Larcombe, Nicholas J. Beeton, Timo Conradi, Henning Nottebrock   +4 more
doaj   +1 more source

Solving the Evidence Interpretability Crisis in Health Technology Assessment: A Role for Mechanistic Models?

Frontiers in Medical Technology, 2022
Health technology assessment (HTA) aims to be a systematic, transparent, unbiased synthesis of clinical efficacy, safety, and value of medical products (MPs) to help policymakers, payers, clinicians, and industry to make informed decisions.
Eulalie Courcelles, Jean-Pierre Boissel, Jacques Massol, Ingrid Klingmann, Riad Kahoul, Marc Hommel, Emmanuel Pham, Alexander Kulesza   +7 more
doaj   +1 more source

Systems immunology: When systems biology meets immunology

Frontiers in Immunology
The immune system is an intricate network of cells, proteins, and signaling pathways that coordinate protective responses and, when dysregulated, drive immune−related diseases.
Lucía Alfonso-González, Lucía Alfonso-González, Francisco J. Fernández, M. Cristina Vega   +3 more
doaj   +1 more source

A Mechanistic Model for Ncd Directionality [PDF]

Journal of Biological Chemistry, 2001
Ncd is a kinesin-related protein that drives movement to the minus-end of microtubules. Pre-steady-state kinetic experiments have been employed to investigate the cooperative interactions between the motor domains of the MC1 dimer and to establish the ATPase mechanism.
K A, Foster, A T, Mackey, S P, Gilbert
openaire   +2 more sources

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

The road to integrate climate change projections with regional land‐use–biodiversity models

People and Nature
Current approaches to project spatial biodiversity responses to climate change mainly focus on the direct effects of climate on species while regarding land use and land cover as constant or prescribed by global land‐use scenarios.
Juliano Sarmento Cabral, Alma Mendoza‐Ponce, André Pinto daSilva, Johannes Oberpriller, Anne Mimet, Julia Kieslinger, Thomas Berger, Jana Blechschmidt, Maximilian Brönner, Alice Classen, Stefan Fallert, Florian Hartig, Christian Hof, Markus Hoffmann, Thomas Knoke, Andreas Krause, Anne Lewerentz, Perdita Pohle, Uta Raeder, Anja Rammig, Sarah Redlich, Sven Rubanschi, Christian Stetter, Wolfgang Weisser, Daniel Vedder, Peter H. Verburg, Damaris Zurell   +26 more
doaj   +1 more source

How to Model Mechanistic Hierarchies [PDF]

Philosophy of Science, 2016
Mechanisms are usually viewed as hierarchical, with lower levels of a mechanism influencing, and decomposing, its higher-level behavior. To draw quantitative predictions from a model of a mechanism, the model must capture this hierarchical aspect. Recursive Bayesian networks (RBNs) were put forward by Lorenzo Casini et al.
openaire   +3 more sources

Mechanistic modeling of viral particle production

Biotechnology and Bioengineering, 2022
AbstractViral systems such as wild‐type viruses, viral vectors, and virus‐like particles are essential components of modern biotechnology and medicine. Despite their importance, the commercial‐scale production of viral systems remains highly inefficient for multiple reasons.
Christopher T. Canova, Pavan K. Inguva, Richard Braatz   +2 more
openaire   +3 more sources