Results 31 to 40 of about 22,796,869 (307)

Mechanistic Modelling of Radiation Responses [PDF]

Cancers, 2019
Radiobiological modelling has been a key part of radiation biology and therapy for many decades, and many aspects of clinical practice are guided by tools such as the linear-quadratic model. However, most of the models in regular clinical use are abstract and empirical, and do not provide significant scope for mechanistic interpretation or making ...
Stephen J. McMahon, Kevin M. Prise
openaire   +4 more sources

BayCANN: Streamlining Bayesian Calibration With Artificial Neural Network Metamodeling

Frontiers in Physiology, 2021
Purpose: Bayesian calibration is generally superior to standard direct-search algorithms in that it estimates the full joint posterior distribution of the calibrated parameters.
Hawre Jalal, Thomas A. Trikalinos, Fernando Alarid-Escudero   +2 more
doaj   +1 more source

A Method to Identify and Analyze Biological Programs through Automated Reasoning. [PDF]

, 2016
Predictive biology is elusive because rigorous, data-constrained, mechanistic models of complex biological systems are difficult to derive and validate.
and Stephen Emmott, 5, Austin Smith, 2, Boyan Yordanov, 1, Hillel Kugler, 1, Martello, Graziano, Sara-Jane Dunn, 1   +5 more
core   +1 more source

Protein folding disorders: Toward a basic biological paradigm [PDF]

, 2010
Mechanistic 'physics' models of protein folding fail to account for the observed spectrum of protein folding and aggregation disorders, suggesting that a more appropriately biological paradigm will be needed for understanding the etiology ...
Rodrick Wallace
core   +3 more sources

A Generalized Mechanistic Codon Model [PDF]

Molecular Biology and Evolution, 2014
Models of codon evolution have attracted particular interest because of their unique capabilities to detect selection forces and their high fit when applied to sequence evolution. We described here a novel approach for modeling codon evolution, which is based on Kronecker product of matrices.
Zaheri Maryam, Dib Linda, Salamin Nicolas   +2 more
openaire   +4 more sources

Emergent global patterns of ecosystem structure and function from a mechanistic general ecosystem model [PDF]

, 2014
Anthropogenic activities are causing widespread degradation of ecosystems worldwide, threatening the ecosystem services upon which all human life depends.
A Friedlander, A Hardisty, B Cho, B Collen, B-E Sæther, BJ McGill, C Mora, C Ward-Paige, CA Deutsch, CB Field, CD Thomas, CEL Ferreira, CH Sekercioglu, CM Duarte, CR McClain, D Griffiths, D Policansky, D Post, D Yates, Derek P. Tittensor, DG Jenkins, Drew W. Purves, DW Purves, E Jeppesen, E Macpherson, E Odum, E Siemann, EA Fulton, FS Chapin, G Krinner, GA Kaufman, GM Mace, H Cyr, H Stibor, HR Peinetti, J Cebrian, J Chase, J Gasol, J Merilä, JA Carton, JE Cohen, JH Brown, JL Frangi, JM Sunday, Jon Hutton, JP Rodríguez, JS Millar, Jörn P. W. Scharlemann, K Rose, KA Nagy, KA Schubert, KE Jones, KR Buck, L Tremblay-Boyer, LLM Fedigan, LW Oring, M Behrenfeld, M González-Suárez, Matthew J. Smith, MBJ Harfoot, ME Power, Michael B. J. Harfoot, Michel Loreau, MJ Coe, MJ Morgan, MJ Smith, MJ Vander Zanden, MK Litvak, MR Evans, MW McCoy, N Blakley, N Loeuille, NG Hairston, O Krüger, P Abrams, P Del Giorgio, PK Holland, R Alkemade, R Bustamante, R Gentile, R Meek, R Shine, R Shine, RE Ricklefs, RE Ricklefs, RJ Williams, RJ Williams, RW Sheldon, RW Wilson, S Díaz, S Fretwell, S Jain, S Jennings, S Jennings, S Meiri, S Sitch, SA Sandin, SD Pletcher, Stephen Emmott, T Newbold, T Sousa, Tim Newbold, TJ Case, TJ Webb, U Brose, V Christensen, Vassily Lyutsarev, W Sprules, X Irigoien, Y-J Shin   +109 more
core   +4 more sources

Real-Time Forecasting of the COVID-19 Outbreak in Chinese Provinces: Machine Learning Approach Using Novel Digital Data and Estimates From Mechanistic Models

Journal of Medical Internet Research, 2020
Background The inherent difficulty of identifying and monitoring emerging outbreaks caused by novel pathogens can lead to their rapid spread; and if left unchecked, they may become major public health threats to the planet.
C. Poirier, Dianbo Liu, L. Clemente, Xiyu Ding, Matteo Chinazzi, Jessica T. Davis, Alessandro Vespignani, M. Santillana   +7 more
semanticscholar   +1 more source

Mechanistic model of hormonal contraception

PLOS Computational Biology, 2020
Contraceptive drugs intended for family planning are used by the majority of married or in-union women in almost all regions of the world. The two most prevalent types of hormones associated with contraception are synthetic estrogens and progestins. Hormonal based contraceptives contain a dose of a synthetic progesterone (progestin) or a combination of
A. Armean Wright, Ghassan N. Fayad, James F. Selgrade, Mette S. Olufsen   +3 more
openaire   +4 more sources

Mechanistic modeling of viral particle production

Biotechnology and Bioengineering, 2022
AbstractViral systems such as wild‐type viruses, viral vectors, and virus‐like particles are essential components of modern biotechnology and medicine. Despite their importance, the commercial‐scale production of viral systems remains highly inefficient for multiple reasons.
Christopher T. Canova, Pavan K. Inguva, Richard D. Braatz   +2 more
openaire   +2 more sources

Statistical inference in mechanistic models: time warping for improved gradient matching [PDF]

, 2017
Inference in mechanistic models of non-linear differential equations is a challenging problem in current computational statistics. Due to the high computational costs of numerically solving the differential equations in every step of an iterative ...
Filippone, Maurizio, Husmeier, Dirk, Macdonald, Benn, Niu, Mu, Rogers, Simon   +4 more
core   +1 more source