Results 171 to 180 of about 584 (208)

Novel Pathogenic Variant in Exon 31 of the TSC2 Gene Associated With a Severe Phenotype of Tuberous Sclerosis

Annals of the Child Neurology Society, EarlyView.
Tabitha D'souza, Laura Davids, Prabhumallikarjun Patil   +2 more
wiley   +1 more source

Suppression of TRPV5 Regulates Microglia‐Mediated Neuroinflammation Following Status Epilepticus

Glia, EarlyView.
TRPV5 is involved in microglial activation following epileptic seizures. TRPV5 upregulation in microglia drives neuroinflammation. TRPV5 inhibition by econazole reduces neuroinflammation via suppressing AKT/NF‐κB/NLRP3 signaling cascade. ABSTRACT Neuroinflammation, predominantly associated with glial activation and the release of various inflammatory ...
Soojin Park, Se Hoon Kim, Chul Hoon Kim, Kyoung Hoon Jeong, Won‐Joo Kim   +4 more
wiley   +1 more source

The mechanisms in glucose metabolism of aging hippocampus

Ibrain, EarlyView.
Cognitive decline in elders stems from the irreversible loss and functional decline of neurons, with the hippocampus being particularly susceptible to age‐related neuronal deterioration. Glucose acts as the primary fuel for the brain, and a constant provision of glucose to the hippocampus is essential for memory and cognitive functions.
Rui He, Fuxing Zhao, Zhiyu Yang, Tingting Wang, Yaohui Zhang, Jinglan Quan, Gaohong Zhu   +6 more
wiley   +1 more source

Rewriting the MASLD‐associated hepatocellular carcinoma script: Targeting epigenetics and metabolism

International Journal of Cancer, EarlyView.
Abstract Abnormal epigenetic patterns are crucial for the progression of metabolic‐associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC) development. Recent research focused on the interplay between epigenetics and altered metabolic pathways in HCC from MASLD, suggesting that the reversibility of epigenetic changes offers ...
Chiara Aiello, Eric Felli, Teresa Musarra, Lorenzo Nevi, Annamaria Altomare, Jordi Gracia‐Sancho, Andrea Baiocchini, Simone Carotti   +7 more
wiley   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

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Metabolomic and Lipidomic Signature of Skeletal Muscle with Constitutively Active Mechanistic Target of Rapamycin Complex 1

The Journal of Nutrition, 2023
Regulation of mechanistic target of rapamycin complex 1 (mTORC1) plays an important role in aging and nutrition. For example, caloric restriction reduces mTORC1 signaling and extends lifespan, whereas nutrient abundance and obesity increase mTORC1 signaling and reduce lifespan.
Rosario Maroto, Ted G Graber, Trevor B Romsdahl, Andrzej Kudlicki, William K Russell, Blake B Rasmussen   +5 more
openaire   +2 more sources

Amino acid sensing and activation of mechanistic target of rapamycin complex 1

Current Opinion in Clinical Nutrition and Metabolic Care, 2016
This article evaluates recent studies on the mechanisms involved in sensing changes in amino acid availability and activation of the mechanistic target of rapamycin complex 1 (mTORC1).mTORC1 is sensitive to changes in amino acid availability and a well known regulator of protein turnover.
Gordon S. Lynch, Daniel J. Ham, René Koopman   +2 more
openaire   +2 more sources

Targeting Mechanistic Target of Rapamycin Complex 1 Restricts Proinflammatory T Cell Differentiation and Ameliorates Takayasu Arteritis

Arthritis & Rheumatology, 2019
ObjectiveTakayasu arteritis (TAK) is a progressive autoimmune large vessel vasculitis with infiltration of proinflammatory T cells, with a largely unknown etiology. This study was undertaken to explore the involvement of mechanistic target of rapamycin (mTOR) in proinflammatory T cell differentiation and disease progression in TAK.MethodsNinety‐five ...
Jifeng Zhang, Lei Zhao, Jing Wang, Zhihua Cheng, Mengyao Sun, Jiayi Zhao, Bin Liu, Xiyu Liu, Zhenke Wen, Zhibo Li   +9 more
openaire   +3 more sources

Mechanistic target of rapamycin complex 1 is involved in psoriasis and regulated by anti‐TNF‐α treatment

Experimental Dermatology, 2017
The mechanistic target of rapamycin (mTOR) acts through two distinct signalling complexes, known as mTOR complex (mTORC) 1 and mTORC2. One of the main upstream regulator of mTORC1 is tumour necrosis factor (TNF)-α, an important pro-inflammatory cytokine involved in psoriasis.
BALATO, ANNA, Lembo, Serena, AYALA, FABIO, BALATO, NICOLA, CAIAZZO, GIUSEPPINA, RAIMONDO, ANNUNZIATA, DI CAPRIO, ROBERTA, MONFRECOLA, GIUSEPPE   +7 more
openaire   +4 more sources

Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema

American Journal of Respiratory and Critical Care Medicine, 2016
The potent immunomodulatory cytokine IL-6 is consistently up-regulated in human lungs with emphysema and in mouse emphysema models; however, the mechanisms by which IL-6 promotes emphysema remain obscure. IL-6 signals using two distinct modes: classical signaling via its membrane-bound IL-6 receptor (IL-6R), and trans-signaling via a naturally ...
Ruwanpura, S.M., McLeod, L., Dousha, L.F., Seow, H.J., Alhayyani, S., Tate, M.D., Deswaerte, V., Brooks, G.D., Bozinovski, S., MacDonald, M., Garbers, C., King, P.T., Bardin, P.G., Vlahos, R., Rose-John, S., Anderson, G.P., Jenkins, B.J.   +16 more
openaire   +4 more sources