Results 151 to 160 of about 47,262 (255)

The mechanistic target of rapamycin complex 1 controls lipid and lactose synthesis in bovine mammary epithelial cells

, 2019
The objective of this study was to assess the role of the mechanistic target of rapamycin complex 1 (mTORC1) on lipid and lactose synthesis in bovine mammary epithelial cells (BMECs). Cells isolated from the mammary tissue of 3 lactating Holstein cows by
Guesthier, Marc-Antoine
core  

ASSESSING THE MECHANISTIC TARGET OF RAPAMYCIN COMPLEX-1 PATHWAY IN RESPONSE TO RESISTANCE EXERCISE AND FEEDING IN HUMAN SKELETAL MUSCLE by MULTIPLEX ASSAY

, 2018
Background: The mechanistic target of rapamycin complex-1 (mTORC-1) is a key nutrient and contraction-sensitive protein that regulates a pathway leading to skeletal muscle growth.
Tsakiridis, Evangelia Evelyn, Tsakiridis, Evangelia, Sara Y. Oikawa, Stuart M. Phillips, Oikawa, Sara Y, Evangelia Tsakiridis, Everson A. Nunes, McGlory, Chris, Nunes, Everson A, Chris McGlory, Phillips, Stuart M   +10 more
core   +1 more source

Long Noncoding RNA H19 Mediates STAT3‐Dependent Activation of Keratinocytes and Fibroblasts in Systemic Sclerosis Skin

Arthritis &Rheumatology, EarlyView.
Objective Dermal systemic sclerosis (SSc) fibroblasts and their exosomes can activate keratinocytes in SSc, with long noncoding RNA (lncRNA) H19 highlighted as the most up‐regulated RNA in their cargo compared with healthy controls (HCs). The role of H19 in SSc pathogenesis has never been investigated.
Begoña Caballero‐Ruiz, Christopher W. Wasson, Rebecca L. Ross, Francesco Del Galdo   +3 more
wiley   +1 more source

Impact of Rapamycin on Genome Organization [PDF]

, 2018
Rapamycin, a putative anti-aging drug, has been shown to extend the lifespan of several model organisms. Rapamycin’s core effect is to inhibit a major nutrient sensing pathway of the cell, mechanistic Target of Rapamycin Complex 1 (mTORC1).
Pickering, Josh AD 1988-
core  

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

Activation of mechanistic target of rapamycin complex 1: the common link between rheumatoid arthritis and diabetes mellitus [PDF]

Rheumatology, 2018
Valerio, De Vita, Bodo C, Melnik
openaire   +2 more sources

Optimal dosing for vascular anomalies paediatric patients with population pharmacokinetic model of sirolimus

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Sirolimus is currently used off‐label for paediatric patients with vascular anomalies. However, the optimal dosage regimen for paediatric patients remains controversial. This study aimed to determine the optimal dosing regimen of sirolimus in these patients using a population pharmacokinetic (PK) model.
Seongmee Jeong, Jungryul Kim, Woojin Jung, Jiyeon Jeon, Hyeongjun Jo, Kyoung‐Bin Ryu, Ja‐Young Hong, Kwan Soo Kim, Seongjun Yang, Hee Young Ju, Hwi‐yeol Yun, Jung‐woo Chae, Keon Hee Yoo, Soyoung Lee   +13 more
wiley   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Activated Protein Phosphatase 2A Disrupts Nutrient Sensing Balance Between Mechanistic Target of Rapamycin Complex 1 and Adenosine Monophosphate-Activated Protein Kinase, Causing Sarcopenia in Alcohol-Associated Liver Disease. [PDF]

Hepatology, 2021
Davuluri G, Welch N, Sekar J, Gangadhariah M, Alsabbagh Alchirazi K, Mohan ML, Kumar A, Kant S, Thapaliya S, Stine M, McMullen MR, McCullough RL, Stark GR, Nagy LE, Naga Prasad SV, Dasarathy S.   +15 more
europepmc   +1 more source