Results 131 to 140 of about 47,262 (255)

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Sleep Disturbances in Adults With Tuberous Sclerosis Complex: Influences of Treatment and Clinical Features

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Tuberous sclerosis complex (TSC) is a genetic condition with multisystem neurocutaneous signs, including hamartomas, epilepsy, and neuropsychological difficulties. Although sleep disorders are increasingly recognized in TSC, they remain poorly described in adults.
Kirstin A. Risgaard, Laura Farach, Hope Northrup, Sarah L. Wilson, Deborah Pearson, Syed Hashmi, Kate Richardson   +6 more
wiley   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis Complex

Nature Communications
Tuberous Sclerosis Complex (TSC) is caused by TSC1 or TSC2 mutations, leading to hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) and lesions  in multiple organs including lung (lymphangioleiomyomatosis) and kidney (angiomyolipoma ...
Nicola Alesi, Damir Khabibullin, Dean M. Rosenthal, Elie W. Akl, Pieter M. Cory, Michel Alchoueiry, Samer Salem, Melissa Daou, William F. Gibbons, Jennifer A. Chen, Long Zhang, Harilaos Filippakis, Laura Graciotti, Caterina Miceli, Jlenia Monfregola, Claudia Vilardo, Manrico Morroni, Chiara Di Malta, Gennaro Napolitano, Andrea Ballabio, Elizabeth P. Henske   +20 more
doaj   +1 more source

Cortisol promotes placental glucose and amino acids transport by activating the mechanistic target of rapamycin complex 1 signaling pathway

Journal of Animal Science
Abstract Low birth weight (LBW) has been an important problem in animal husbandry, contributing to high mortality and morbidity rates in the neonatal period. To explore the mechanism regulating placental function and fetal development, paired normal birth weight (NBW, 1.54 ± 0.08 kg) and LBW (0.95 ± 0.16 kg) piglets (n = 10) were ...
Rui Zhou, Zhipeng Wang, Tianle Gao, Liang Hu, Hong Chen, Teng Hui, Ran Li, Xiaoling Zhang, Lingjie Huang, Yong Zhuo, Zhengfeng Fang   +10 more
openaire   +2 more sources

Novel roles for the MAPK-interacting serine threonine kinases (Mnks)

, 2013
The mitogen activated protein kinase (MAPK)-interacting serine threonine kinases (Mnks) are components of the MEK/ERK and p38MAPK signalling pathways.
Stead, Rebecca
core  

Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise

, 2015
The present study aimed to investigate the role of the mechanistic target of rapamycin complex 1 (mTORC1) in the regulation of myofibrillar (MyoPS) and mitochondrial (MitoPS) protein synthesis following endurance exercise.
Jeromson, Stewart, Phillips, Stuart M., Laverone, Erin, Baar, Keith, Breen, Leigh, Perez-Schindler, Joaquin, Hamilton, David Lee, Hamilton, D. lee, Philp, Andrew, Phillips, Stuart M, Schenk, Simon   +10 more
core   +1 more source

Exploring the association between acne and metabolic syndrome in patients from North-Eastern India: a cross-sectional study in a tertiary care setting

Revista da Sociedade Portuguesa de Dermatologia e Venereologia
Objectives: Acne vulgaris is increasingly considered not just as a dermatological condition, but as a manifestation of broader systemic disturbances, including metabolic imbalance and hormonal dysregulation, with emerging evidence linking it to insulin ...
Shikha Verma, Aniket Goswami, Binod K. Thakur, Kaustubh Bora, Alice A. Ruram   +4 more
doaj  

The role of cellular signalling pathways and translation initiation factors in Herpesvirus infection [PDF]

, 2011
As obligate intracellular parasites, viruses rely on host cells to replicate. Hsv-1 is a large double stranded DNA virus which is the cause of common cold sores and corneal blindness in humans. The defining feature of HSV-1 is its ability to exist in two
McMahon, Robert
core