Results 201 to 210 of about 35,268 (338)

Mechanobiology of dynamic enzyme systems [PDF]

, 2020
Peter J. Butler
openalex   +1 more source

Synthetic Cell‐Based Artificial Stem Cell Niches for Hematopoietic Stem Cell Differentiation

ChemBioChem, Volume 27, Issue 8, April 2026.
Hematopoietic stem cells (HSCs) receive a combination of biochemical and biomechanical signals within the bone marrow that guide their differentiation process. These include soluble factor signaling with cytokines, cellular confinement in the stem cell niche, and contact‐dependent receptor–ligand interactions with stromal cells. Recreating this complex
Ivaylo Balabanov, Sara Madureira, Anna Burgstaller, Maja Fehlberg, Nils Piernitzki, Nurzhan Abdukarimov, Franziska Lautenschläger, Oskar Staufer   +7 more
wiley   +1 more source

Lattice Structures for Bone Replacement: The Intersection of Bone Biomechanics, Lattice Design, and Additive Manufacturing

Advanced Materials Technologies, Volume 11, Issue 7, 6 April 2026.
This review outlines how understanding bone's biology, hierarchical architecture, and mechanical anisotropy informs the design of lattice structures that replicate bone morphology and mechanical behavior. Additive manufacturing enables the fabrication of orthopedic implants that incorporate such structures using a range of engineering materials ...
Stylianos Kechagias, Maxwell J. Munford, Frederik C.H. Masure, Richard J. van Arkel, Reece N Oosterbeek   +4 more
wiley   +1 more source

Two‐Photon Polymerized Microvascular Environments for Multicellular Modeling of the Blood–Brain Tumor Barrier

Advanced Materials Technologies, Volume 11, Issue 8, 17 April 2026.
Modeling the blood–brain tumor barrier is challenging due to complex interactions between brain microvasculature and glioma cells. We present two‐photon polymerized 3D micro‐porous capillary‐like structures that support endothelial alignment, cytoskeletal organization, and pericyte‐endothelial‐glioma tri‐cultures.
Nastaran Barin, Sayba Z. Chowdhury, Maurice de Wit, Rania Head, Kiki Bals, Erwin Brosens, Marvin M. van Luijn, Hayri E. Balcioglu, Angelo Accardo, Pim J. French   +9 more
wiley   +1 more source

A Novel, Open-Source, Low-Cost, Uniaxial Strain Bioreactor for 3D Soft Tissue Mechanobiology Applications

Johannes Peter Schramel, Shru R, Florien Jenner, Stephan Handschuh, Ursula Reichert   +4 more
openalex   +2 more sources

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Maths in Medicine: How to Survive a Science Fair

, 2016
When talking to secondary school students, first impressions are crucial. Accidentally say something that sounds boring and you'll lose them in seconds. A physical demonstration can be an eye-catching way to begin an activity or spark off a conversation ...
Pearce, Philip, Shearer, Tom
core  

OS5-6 Incorporation of hydrogel and electrospun scaffolds induces skeletal myoblasts differentiation(OS5: Mechanobiology and Tissue Engineering for Disease and Regeneration II)

, 2015
Ung Hyun Ko, Thai Le Phuong Anh, Jun-Ho Lee, Suk-Hee Park, Jennifer H. Shin   +4 more
openalex   +1 more source

A Conformal Wearable Ultrasound Bioelectronics for Mechanotherapy Reprogramming of Fibroblast Plasticity via Wnt‐FGF10 Axis to Overcome Fibrotic Healing in Urethral Regeneration

Advanced Science, Volume 13, Issue 24, 27 April 2026.
Fibrotic scarring persistently challenges urethral reconstruction. This study introduces a conformal, wearable ultrasound bioelectronic system that overcomes this by reprogramming fibroblast fate. The device activates a developmental Wnt–FGF10 axis, driving fibroblasts toward a regenerative FGF10+ phenotype that promotes angiogenesis and matrix ...
Mingming Yu, Xingxuan Zhang, Huan Zhang, Jun Wang, Fang Chen, Xiaojun Cai, Yichen Huang, Yuanyi Zheng   +7 more
wiley   +1 more source

Could the Phenotypic Outcomes of Genetic Variability in Cells Operating in Mechanically Dynamic Environments be Influenced by a Disrupted “Cell‐ECM” Relationship? Using Cystic Fibrosis and Marfan Syndrome as an Example

BioEssays, Volume 48, Issue 4, April 2026.
The “Cell‐Extracellular Matrix Unit” in a mechanically active environment (Centre). Mutations in ECM molecules such as fibrillin‐1 can lead to Marfan Syndrome (A), while mutations in the cellular CFTR can lead to Cystic Fibrosis (B). A combination of such mutations without a clinical phenotype alone could also lead to disease (C). ABSTRACT Diseases due
David A. Hart
wiley   +1 more source