Results 11 to 20 of about 5,456 (165)
The tandem-random transition of cellular patterning: proposed roles of N-cadherin-based orientational cell adhesions in the development, maintenance, and degeneration of the nucleus pulposus. [PDF]
Biol Rev Camb Philos SocABSTRACT Intervertebral disc degeneration (IDD) can contribute to lower back and neck pain. In IDD, the most affected component of the intervertebral disc is the nucleus pulposus (NP). Derived from the notochord, where cells are organized into a tandem configuration, young NP cells cluster in three‐dimensional (3D) networks embedded in a gelatinous ...
Wei X, Vo N, Sowa GA.
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Emerging Topics in Life Sciences, 2018 Structural links from the nucleus to the cytoskeleton and to the extracellular environment play a role in direct mechanosensing by nuclear factors. Here, we highlight recent studies that illustrate nuclear mechanosensation processes ranging from DNA repair and nuclear protein phospho-modulation to chromatin reorganization, lipase activation by dilation,
Yuntao Xia +4 more
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Assaying mechanosensation [PDF]
WormBook, 2014 C. elegans detect and respond to diverse mechanical stimuli using neuronal circuitry that has been defined by decades of work by C. elegans researchers. In this WormMethods chapter, we review and comment on the techniques currently used to assess mechanosensory response. This methods review is intended both as an introduction for those new to the field
Martin, Chalfie +3 more
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Mechanosensation in leaf veins [PDF]
Science Advances, 2023 Whether the plant vasculature has the capacity to sense touch is unknown. We developed a quantitative assay to investigate touch-response electrical signals in the leaves and veins of Arabidopsis thaliana . Mechanostimulated electrical signaling in leaves displayed strong diel regulation.
Tsu-Hao Yang +3 more
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Mechanosensing and fibrosis [PDF]
Journal of Clinical Investigation, 2018 Tissue injury disrupts the mechanical homeostasis that underlies normal tissue architecture and function. The failure to resolve injury and restore homeostasis gives rise to progressive fibrosis that is accompanied by persistent alterations in the mechanical environment as a consequence of pathological matrix deposition and stiffening.
Daniel J. Tschumperlin +3 more
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Channelling the Force to Reprogram the Matrix: Mechanosensitive Ion Channels in Cardiac Fibroblasts
Cells, 2021 Cardiac fibroblasts (CF) play a pivotal role in preserving myocardial function and integrity of the heart tissue after injury, but also contribute to future susceptibility to heart failure. CF sense changes to the cardiac environment through chemical and
Leander Stewart, Neil A. Turner
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Microtubule Acetylation Is Required for Mechanosensation in Drosophila
Cell Reports, 2018 Summary: At the cellular level, α-tubulin acetylation alters the structure of microtubules to render them mechanically resistant to compressive forces. How this biochemical property of microtubule acetylation relates to mechanosensation remains unknown ...
Connie Yan +16 more
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Mechanotransduction events at the physiological site of touch detection
eLife, 2023 Afferents of peripheral mechanoreceptors innervate the skin of vertebrates, where they detect physical touch via mechanically gated ion channels (mechanotransducers).
Luke H Ziolkowski +2 more
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Distinct roles for innexin gap junctions and hemichannels in mechanosensation
eLife, 2020 Mechanosensation is central to a wide range of functions, including tactile and pain perception, hearing, proprioception, and control of blood pressure, but identifying the molecules underlying mechanotransduction has proved challenging.
Denise S Walker, William R Schafer
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Analysis of the mechanosensor channel functionality of TACAN
eLife, 2021 Mechanosensitive ion channels mediate transmembrane ion currents activated by mechanical forces. A mechanosensitive ion channel called TACAN was recently reported.
Yiming Niu +6 more
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