Oligodendrocyte Piezo2 is a regulator of age-dependent myelin integrity and dysregulated in multiple sclerosis [PDF]
Communications BiologyStudies on the mechanosensitive ion channel Piezo2 largely focus on its role in the peripheral nervous system, particularly in touch and pain sensation.
Julia Dyckow-Schubart +12 more
doaj +2 more sources
BDNF-TrκB-PLCγ signaling drives BPA-induced mechanical allodynia through activating mechanosensitive Piezo2 channels [PDF]
Cell & BioscienceBackground Brachial plexus avulsion (BPA) induced neuropathic pain (NP) affects up to 90% patients with BPA, which is often characterized by mechanical allodynia.
Yuan-Ying Liu +6 more
doaj +2 more sources
A dual role of PIEZO2 in neuropathic pain: driving peripheral sensitization and enabling mechanical loading-induced analgesia [PDF]
Cell Communication and SignalingBackground Mechanotherapy, a form of mechanical loading (ML), effectively relieves tactile allodynia-associated neuropathic pain by targeting sensitization points stimulated by PIEZO2, a mechanosensitive ion channel.
Chongjie Yao +10 more
doaj +2 more sources
Piezo channels contribute to the terminal cytodifferentiation of odontoblasts via modulation of canonical Wnt signaling [PDF]
International Journal of Oral SciencePiezo1 and Piezo2 are mechanosensitive ion channels that transduce mechanical stimuli into intracellular biochemical signals in diverse tissues and organ systems. Their functions in odontoblast development are still not well understood. In this study, we
Xuguang Nie +3 more
doaj +2 more sources
Gut MicrobesThe gut microbiota plays a crucial role in the manifestation of intestinal dysfunction associated with irritable bowel syndrome (IBS). The mechanosensory Piezo2 has been implicated in the regulation of intestinal function.
Li Ping Duan, Jindong Zhang, Chang Liu
exaly +3 more sources
Acupuncture alleviates osteoarthritis pain by remodeling the DRG neuro-immune microenvironment via Piezo2-mediated macrophage polarization [PDF]
Frontiers in ImmunologyBackgroundOsteoarthritis (OA) pain is predominantly characterized by mechanical allodynia, and dorsal root ganglion (DRG) neuro-immune crosstalk serves as a critical driver of peripheral sensitization.
Tianran Tang +8 more
doaj +2 more sources
Blockade of Piezo2 Pathway Attenuates Inflammatory and Neuropathic Pain in the Orofacial Area
Pain Research and ManagementAlthough previous studies suggest that Piezo2 regulates chronic pain in the orofacial area, few studies have reported the direct evidence of Piezo2’s involvement in inflammatory and neuropathic pain in the orofacial region.
Dong K Ahn, Jin-Sook Ju, Jo-Young Son
exaly +2 more sources
Müller Glia-Vasculature Interactions in the Developing Retina. [PDF]
GliaRetinal vascular layers form normally despite loss of cholinergic retinal waves. Müller glial processes contact endothelial tip cells early and form Aquaporin‐4‐enriched endfeet. Glial endfoot calcium signals are compartmentalized and occur largely independently of neural activity. ABSTRACT Coordinated signaling among neurons, glia, and the vasculature
Monshietehadi S +6 more
europepmc +2 more sources
Contribution of Piezo2 to Endothelium-Dependent Pain
Molecular Pain, 2015 Background We evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced ...
Paul G. Green, Jon D Levine
exaly +2 more sources
Immunohistochemical Detection of the Mechano-Gated Piezo Channels in the Normal Endometrium and in Endometriosis [PDF]
BiomoleculesEndometriosis is an inflammatory estrogen-dependent disorder characterized by pain, dyspareunia, dysmenorrhea, and infertility. This is due to the invasion of different organs by endometrial tissue that causes inflammation, angiogenesis, and fibrosis ...
Angel Sánchez del Rio +7 more
doaj +2 more sources