Results 21 to 30 of about 4,014 (160)

Клинико-генетические характеристики дистальных артрогрипозов, обусловленных мутациями в гене PIEZO2 [PDF]

, 2021
Mutations in the PIEZO2 gene, which is involved in the formation of the mechanosensitive cation channel Piezo2, can cause distal arthrogryposis type 3 (Gordon’s syndrome), type 5, and Marden–Walker syndrome.
А. Ф. Муртазина, Е. Л. Дадали, С. С. Никитин, S. S. Nikitin, T. V. Markova, O. L.  Mironovich, Т. В. Маркова, E. L. Dadali, О. Л. Миронович, И. В. Канивец, A.  F . Murtazina, I.  V.   Kanivets   +11 more
core   +1 more source

Potentiation of PIEZO2 mechanically-activated currents in sensory neurons mediates vincristine-induced mechanical hypersensitivity

Acta Pharmaceutica Sinica B, 2023
Vincristine, a widely used chemotherapeutic agent for treating different cancer, often induces severe peripheral neuropathic pain. A common symptom of vincristine-induced peripheral neuropathic pain is mechanical allodynia and hyperalgesia.
Mingli Duan, Yurui Jia, Lifang Huo, Yiting Gao, Jia Wang, Wei Zhang, Zhanfeng Jia   +6 more
doaj   +1 more source

Piezo2 tension sensitivity and its modulation by alternative splicing. [PDF]

Cell Rep
Piezo2 is a force-gated ion channel that functions as a sensor of mechanical touch, proprioception, lung inflation, and gut transit. Human Piezo2 contains seven domains that are alternatively spliced in a tissue-specific fashion resulting in the ...
Sindoni M, Sharp W, Grandl J.
europepmc   +2 more sources

Piezo2—peripheral baroreceptor channel expressed in select neurons of the mouse brain: a putative mechanism for synchronizing neural networks by transducing intracranial pressure pulses

Journal of Integrative Neuroscience, 2021
Here we use immunohistochemistry to examine the expression of Piezo2 in neurons of the mouse dorsal root ganglia and brain. Whereas Piezo2 is expressed in the large majority (≥ 90%) of dorsal root ganglia neurons, Piezo2 expression is restricted to ...
Jigong Wang, Owen P. Hamill   +1 more
doaj   +1 more source

206 The Role of Mechanosensitive Ion Channels in Primary Open Angle Glaucoma

Journal of Clinical and Translational Science, 2022
OBJECTIVES/GOALS: Intraocular pressure is the most significant risk factor for glaucoma. Mechanosensitive proteins may have a critical role in transducing mechanical stimuli that ultimately lead to death of retinal ganglion cells.
Wendy Liu, Ying Zhu, Tatjana Jakobs, Janey Wiggs   +3 more
doaj   +1 more source

Piezo2 channels.

, 2023
The ions flow generated in Piezo2 channels under different indentation depths. triangle line: experimental results from [36], solid line: simulation results(d0 = 5.8μm, d0 = 6.7μm, d0 = 7.0μm, d0 = 7.3μm, d0 = 7.6μm, d0 = 7.9μm).
Wenzhen Yang (4093081), Fangtao Mao (17684313)   +1 more
core   +1 more source

Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice

Nature Communications, 2023
The mechanosensitive ion channel Piezo2 in mucosa and primary afferents transduces colonic mechanical sensation. Here we show that chemogenetic activation or nociceptor-targeted deletion of Piezo2 is sufficient to regulate colonic mechanical sensitivity ...
Jonathan Madar, Namrata Tiwari, Cristina Smith, Divya Sharma, Shanwei Shen, Alsiddig Elmahdi, Liya Y. Qiao   +6 more
doaj   +1 more source

Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons

eLife, 2018
Piezo2 ion channels are critical determinants of the sense of light touch in vertebrates. Yet, their regulation is only incompletely understood. We recently identified myotubularin related protein-2 (Mtmr2), a phosphoinositide (PI) phosphatase, in the ...
Pratibha Narayanan, Meike Hütte, Galina Kudryasheva, Francisco J Taberner, Stefan G Lechner, Florian Rehfeldt, David Gomez-Varela, Manuela Schmidt   +7 more
doaj   +1 more source

Piezo2 expression and its alteration by mechanical forces in mouse mesangial cells and renin-producing cells

Scientific Reports, 2022
The kidney plays a central role in body fluid homeostasis. Cells in the glomeruli and juxtaglomerular apparatus sense mechanical forces and modulate glomerular filtration and renin release.
Yuki Mochida, Koji Ochiai, Takashi Nagase, Keiko Nonomura, Yoshihiro Akimoto, Hiroshi Fukuhara, Tatsuo Sakai, George Matsumura, Yoshihiro Yamaguchi, Miki Nagase   +9 more
doaj   +1 more source

Intrinsically disordered intracellular domains control key features of the mechanically-gated ion channel PIEZO2

, 2022
A central question in mechanobiology is how mechanical forces acting in or on cells are transmitted to mechanically-gated PIEZO channels that convert these forces into biochemical signals. Here we examined the role of the intracellular domains of PIEZO2,
Verkest, Clement, Nees, Timo A., Schaefer, Irina, Taberner, Francisco J., Jegelka, Juri M., Lechner, Stefan G., Wang, Na   +6 more
core   +1 more source