Results 11 to 20 of about 4,014 (160)

Piezo2 is not an indispensable mechanosensor in murine cardiomyocytes

Scientific Reports, 2022
A short-term increase in ventricular filling leads to an immediate (Frank-Starling mechanism) and a slower (Anrep effect) rise in cardiac contractility, while long-term increased cardiac load (e.g., in arterial hypertension) decreases contractility ...
Benjamin Kloth, Giulia Mearini, Florian Weinberger, Justus Stenzig, Birgit Geertz, Jutta Starbatty, Diana Lindner, Udo Schumacher, Hermann Reichenspurner, Thomas Eschenhagen, Marc N. Hirt   +10 more
doaj   +2 more sources

Cell-Type-Specific Splicing of Piezo2 Regulates Mechanotransduction

Cell Reports, 2017
Summary: Piezo2 is a mechanically activated ion channel required for touch discrimination, vibration detection, and proprioception. Here, we discovered that Piezo2 is extensively spliced, producing different Piezo2 isoforms with distinct properties ...
Marcin Szczot, Leah A. Pogorzala, Hans Jürgen Solinski, Lynn Young, Philina Yee, Claire E. Le Pichon, Alexander T. Chesler, Mark A. Hoon   +7 more
doaj   +2 more sources

Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents [PDF]

Cell Reports, 2012
Heightened nociceptor function caused by inflammatory mediators such as bradykinin (BK) contributes to increased pain sensitivity (hyperalgesia) to noxious mechanical and thermal stimuli.
Adrienne E. Dubin, Manuela Schmidt, Jayanti Mathur, Matthew J. Petrus, Bailong Xiao, Bertrand Coste, Ardem Patapoutian   +6 more
doaj   +2 more sources

Piezo2 Knockdown Inhibits Noxious Mechanical Stimulation and NGF-Induced Sensitization in A-Delta Bone Afferent Neurons [PDF]

Frontiers in Physiology, 2021
Piezo2 is a mechanically gated ion-channel that has a well-defined role in innocuous mechanical sensitivity, but recently has also been suggested to play a role in mechanically induced pain.
Sara Nencini, Michael Morgan, Jenny Thai, Andrew I. Jobling, Stuart B. Mazzone, Jason J. Ivanusic   +5 more
doaj   +2 more sources

Acquired Piezo2 Channelopathy is One Principal Gateway to Pathophysiology

Frontiers in Bioscience-Landmark
The Piezo2 transmembrane proteins were identified by Ardem Patapoutian and his team. They also found that Piezo2 is the principal mechanosensory ion channel responsible for proprioception.
Balázs Sonkodi
doaj   +2 more sources

Does Proprioception Involve Synchronization with Theta Rhythms by a Novel Piezo2 Initiated Ultrafast VGLUT2 Signaling?

Biophysica, 2023
This opinion manuscript outlines how the hippocampal theta rhythm could receive two novel peripheral inputs. One of the ways this could be achieved is through Piezo2 channels and atypical hippocampal-like metabotropic glutamate receptors coupled to ...
Balázs Sonkodi
doaj   +2 more sources

Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis

Nature Communications, 2023
Non-opioid targets are needed for addressing osteoarthritis pain, which is mechanical in nature and associated with daily activities such as walking and climbing stairs. Piezo2 has been implicated in the development of mechanical pain, but the mechanisms
Alia M. Obeidat, Matthew J. Wood, Natalie S. Adamczyk, Shingo Ishihara, Jun Li, Lai Wang, Dongjun Ren, David A. Bennett, Richard J. Miller, Anne-Marie Malfait, Rachel E. Miller   +10 more
doaj   +2 more sources

Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity

Nature Communications, 2020
Mutations in human PIEZO2, encoding for a mechanosensitive ion channel, lead to skeletal abnormalities including scoliosis and hip dysplasia. Here, the authors show that deletion of Piezo2 in proprioceptive neurons, but not in skeletal lineages ...
Eran Assaraf, Ronen Blecher, Lia Heinemann-Yerushalmi, Sharon Krief, Ron Carmel Vinestock, Inbal E. Biton, Vlad Brumfeld, Ron Rotkopf, Erez Avisar, Gabriel Agar, Elazar Zelzer   +10 more
doaj   +2 more sources

TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction

Cell Reports
Summary: The transmembrane channel-like (TMC) protein family comprises eight members, with TMC1 and TMC2 being extensively studied. This study demonstrates substantial co-expression of TMC7 with the mechanosensitive channel Piezo2 in somatosensory ...
Xiaona Du, Xinmeng Li, Yating An
exaly   +3 more sources

A pan-cancer analysis reveals the genetic alterations and immunotherapy of Piezo2 in human cancer

Frontiers in Genetics, 2022
Background: Piezo2 is a transmembrane-spanning ion channel protein implicated in multiple physiological processes, including cell proliferation and angiogenesis in many cell types.
Xin Liu, Yangpu Jia, Zhihui Wang, Zhihui Wang, Zhaoxiong Zhang, Weihua Fu   +5 more
doaj   +1 more source