Results 21 to 30 of about 5,456 (165)
Frontiers in Cell and Developmental Biology, 2022 Cell–cell mechanical communications at a large spatial scale (above hundreds of micrometers) have been increasingly recognized in recent decade, which shows importance in tissue-level assembly and morphodynamics. The involved mechanosensing mechanism and
Mingxing Ouyang +7 more
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Scientific Reports, 2018 Mechanotransduction is crucial for touch sensation, hearing, proprioception, and pain sensing. In C. elegans, male ray neurons have been implicated to be involved in the mechanosensation required for mating behavior. However, whether ray neurons directly
Hu Zhang +9 more
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The elegance of prickly sensations
eLife, 2022 Neurons sensing harmful mechanical forces in the larvae of fruit flies have a striking architecture of dendrites that are optimized to detect pointy objects.
Bibi Nusreen Imambocus, Peter Soba
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Experimental Models to Study Podocyte Biology: Stock-Taking the Toolbox of Glomerular Research
Frontiers in Pediatrics, 2018 Diseases affecting the glomeruli of the kidney, the renal filtration units, are a leading cause of chronic kidney disease and end-stage renal failure. Despite recent advances in the understanding of glomerular biology, treatment of these disorders has ...
Henning Hagmann, Paul T. Brinkkoetter
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Reevaluation of Piezo1 as a gut RNA sensor
eLife, 2022 Piezo1 is a stretch-gated ion channel required for mechanosensation in many organ systems. Recent findings point to a new role for Piezo1 in the gut, suggesting that it is a sensor of microbial single-stranded RNA (ssRNA) rather than mechanical force. If
Alec R Nickolls +6 more
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Mechanosensing through immunoreceptors
Nature Immunology, 2019 The immune response is orchestrated by a variety of immune cells. The function of each cell is determined by the collective signals from various immunoreceptors, whose expression and activity depend on the developmental stages of the cell and its environmental context.
Cheng Zhu +4 more
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Nucleus Mechanosensing in Cardiomyocytes
International Journal of Molecular Sciences, 2023 Cardiac muscle contraction is distinct from the contraction of other muscle types. The heart continuously undergoes contraction–relaxation cycles throughout an animal’s lifespan. It must respond to constantly varying physical and energetic burdens over the short term on a beat-to-beat basis and relies on different mechanisms over the long term.
Isabella Leite Coscarella +5 more
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Harnessing Mechanosensation in Next Generation Cardiovascular Tissue Engineering
Biomolecules, 2020 The ability of the cells to sense mechanical cues is an integral component of ”social” cell behavior inside tissues with a complex architecture. Through ”mechanosensation” cells are in fact able to decrypt motion, geometries and physical information of ...
Gloria Garoffolo +5 more
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The mechanosensitive Piezo1 channels contribute to the arterial medial calcification
Frontiers in Physiology, 2022 Vascular calcification (VC) is associated with a number of cardiovascular diseases, as well as chronic kidney disease. The role of smooth muscle cells (SMC) has already been widely explored in VC, as has the role of intracellular Ca2+ in regulating SMC ...
László Szabó +16 more
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Frontiers in Cell and Developmental Biology, 2023 Plastin-3 (PLS3) is a calcium-sensitive actin-bundling protein that has recently been linked to the development of childhood-onset osteoporosis. Clinical data suggest that PLS3 mutations lead to a defect in osteoblast function, however the underlying ...
Samantha M. Chin +3 more
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