Results 51 to 60 of about 5,456 (165)
Temporal processing and context dependency in Caenorhabditis elegans response to mechanosensation
eLife, 2018 A quantitative understanding of how sensory signals are transformed into motor outputs places useful constraints on brain function and helps to reveal the brain’s underlying computations. We investigate how the nematode Caenorhabditis elegans responds to
Mochi Liu +3 more
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A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
Mechanosensation: Tethered Ion Channels [PDF]
Current Biology, 2013 Two new studies show that the Drosophila transient receptor potential (TRP) family member NOMPC forms both a mechanically gated ion channel and a fine filament that, by tethering the protein to microtubules, might act as a gating spring.
Zanini, Damiano, Göpfert, Martin C.
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Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
The Journal of Physiology, EarlyView.Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò +18 more
wiley +1 more source
TMEM120A/TACAN: A putative regulator of ion channels, mechanosensation, and lipid metabolism
Channels, 2023 TMEM120A (TACAN) is an enigmatic protein with several seemingly unconnected functions. It was proposed to be an ion channel involved in sensing mechanical stimuli, and knockdown/knockout experiments have implicated that TMEM120A may be necessary for ...
Matthew Gabrielle, Tibor Rohacs
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The Journal of Physiology, EarlyView.Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise +2 more
wiley +1 more source
Mechanosensing tensile solid stresses [PDF]
Proceedings of the National Academy of Sciences, 2019 Experiments and modeling over the past decade have concluded that cells use sophisticated molecular “clutches” at focal adhesions to determine the stiffness of their supporting substrate (1). This mechanism has been shown to modulate a variety of cell functions, including differentiation and migration. In PNAS, Panzetta et al.
Lance L, Munn, Hadi T, Nia
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Epidemiological Insights Into Polycystic Liver Disease: Data From Forensic Autopsies in Portugal
Liver International Communications, Volume 7, Issue 1, March 2026.ABSTRACT Polycystic liver disease (PLD) is a rare hereditary disorder characterised by multiple hepatic cysts, occurring either in isolation or in association with autosomal dominant polycystic kidney disease (ADPKD). Population‐based prevalence data are scarce, and no national data are available for Portugal.
Laura Martins +2 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 5, Page 1122-1139, March 2026.Abstract Background and Purpose Mavacamten (MAVA) is a novel small molecule inhibitor of cardiac myosin, mitigating cardiomyocyte hypercontractility in patients with hypertrophic obstructive cardiomyopathy (HOCM). Despite its recent approval for clinical use, the transcriptional and functional impacts of MAVA remain not well understood.
Elisa Kiselev +36 more
wiley +1 more source
Molecular mechanisms of cellular mechanosensing [PDF]
Nature Materials, 2013 Mechanical forces direct a host of cellular and tissue processes. Although much emphasis has been placed on cell-adhesion complexes as force sensors, the forces must nevertheless be transmitted through the cortical cytoskeleton. Yet how the actin cortex senses and transmits forces and how cytoskeletal proteins interact in response to the forces is ...
Tianzhi Luo +3 more
openaire +2 more sources