Results 71 to 80 of about 5,456 (165)

Filamins in Mechanosensing and Signaling [PDF]

open access: yesAnnual Review of Biophysics, 2012
Filamins are essential, evolutionarily conserved, modular, multidomain, actin-binding proteins that organize the actin cytoskeleton and maintain extracellular matrix connections by anchoring actin filaments to transmembrane receptors. By cross-linking and anchoring actin filaments, filamins stabilize the plasma membrane, provide cellular cortical ...
Ziba, Razinia   +3 more
openaire   +2 more sources

How larvae feel the world around them

open access: yeseLife
A complete map of the external sense organs shows how fruit fly larvae detect different aspects of their environment.
Jimena Berni
doaj   +1 more source

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren   +4 more
wiley   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

open access: yesCell Proliferation, Volume 59, Issue 2, February 2026.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie   +10 more
wiley   +1 more source

A Novel Core–Shell Hydrogel 3D Model for Studying Macrophage Mechanosensing and Foreign Body Giant Cell Formation

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 3, 19 January 2026.
The foreign body response (FBR) to biomaterials is primarily driven by macrophages, which often fuse into destructive foreign body giant cells (FBGCs). To address the limited understanding of FBGC formation, a novel microscale core–shell hydrogel 3D model is developed using heterogeneous alginate‐collagen microcapsules with varying stiffness, offering ...
Manisha Mahanty   +5 more
wiley   +1 more source

An inverse problem approach to identify the internal force of a mechanosensation process in a cardiac myocyte

open access: yesInformatics in Medicine Unlocked, 2017
Mechanosensation and mechanotransduction are fundamental processes in understanding the link between physical stimuli and biological responses which currently still remain not well understood. The precise molecular mechanism involved in stress and strain
Serife Arif   +4 more
doaj   +1 more source

Mechanosensing by Vascular Endothelium

open access: yesAnnual Review of Physiology
Mechanical forces influence different cell types in our bodies. Among the earliest forces experienced in mammals is blood movement in the vascular system. Blood flow starts at the embryonic stage and ceases when the heart stops. Blood flow exposes endothelial cells (ECs) that line all blood vessels to hemodynamic forces.
Xin Rui, Lim, Osama F, Harraz
openaire   +2 more sources

Associative Learning of Quantitative Mechanosensory Stimuli in Honeybees

open access: yesInsects
The proboscis extension response (PER) has been widely used to evaluate honeybees’ (Apis mellifera) learning and memory abilities, typically by using odors and visual cues for the conditioned stimuli.
Heather Strelevitz   +2 more
doaj   +1 more source

High-LET Proton Irradiation Significantly Alters the Clonogenic and Tumorigenic Potential of Human Breast Cancer Cell Lines In Vitro and In Vivo

open access: yesFrontiers in Bioscience-Landmark
Background: The implementation of proton beam irradiation (PBI) for breast cancer (BC) treatment is rapidly advancing due to its enhanced target coverage and reduced toxicities to organs at risk.
Margarita Pustovalova   +11 more
doaj   +1 more source

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