Secondary 3‐Chloropiperidines: Powerful Alkylating Agents
ChemistryOpen, Volume 13, Issue 6, June 2024.The synthesis of secondary 3‐chloropiperidines and highly strained bicyclic aziridines is reported, including a new method for the selective mono‐chlorination of unsaturated primary amines. The novel compounds, which closely resemble natural alkylating agents, proved to be more active than previously reported 3‐chloropiperidines in a DNA cleavage assay,
Mats Georg +5 more
wiley +1 more source
Progress in Hodgkin lymphoma: a population-based study on patients diagnosed in Sweden from 1973-2009. [PDF]
, 2012 To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.In recent decades, attention has focused on reducing long-term, treatment-related morbidity and mortality in Hodgkin lymphoma (HL).
Bjorkholm, Magnus +7 more
core +1 more source
Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments [PDF]
, 2017 Signaling networks are nonlinear and complex, involving a large ensemble of dynamic interaction states that fluctuate in space and time. However, therapeutic strategies, such as combination chemotherapy, rarely consider the timing of drug perturbations ...
Blicher Bjerregård, Mathias +9 more
core +3 more sources
Interdisciplinary Toxicology, 2018 Mechlorethamine (HN2) is an alkylating agent and sulfur mustard gas mimetic which is also used in anticancer therapy. HN2 is associated with skin inflammation and blistering which can lead to secondary infections.
Benedette J. Cuffari +3 more
semanticscholar +1 more source
Correction to: The PROVe Study: US Real-World Experience with Chlormethine/Mechlorethamine Gel in Combination with Other Therapies for Patients with Mycosis Fungoides Cutaneous T-Cell Lymphoma [PDF]
, 2022 Ellen J. Kim +8 more
openalex +1 more source
Adult life after surviving lymphoma in childhood [PDF]
, 2018 Introduction: Almost all pediatric lymphomas are malignant, high-grade tumors. The combined incidence of Hodgkin's disease (HD) and non-Hodgkin lymphoma (NHL) reaches 10 to 12 new cases a year per million children under the age of 16years, representing ...
von der Weid, Nicolas
core
Hodgkin disease of thymic origin [PDF]
, 2002 J Thorac Cardiovasc Surg 2002;123:1208 ...
Calvo, María José Roca +4 more
core +3 more sources
Proliferating cell nuclear antigen (PCNA), p53 and MDM2 expression in Hodgkin's disease [PDF]
, 2007 CONTEXT and OBJECTIVE: Tumor cells in Hodgkin's disease (HD) express cell proliferation markers that are evaluated according to the oncogenes involved or the expression of their proteins.
Kerbauy, Jose +4 more
core +3 more sources
Vinblastine, bleomycin, and methotrexate chemotherapy plus irradiation for patients with early-stage, favorable Hodgkin lymphoma - The experience of the gruppo italiano studio linfomi [PDF]
, 2003 BACKGROUND. The acknowledged effectiveness of vinblastine, bleomycin, and methotrexate (VBM) chemotherapy in patients with early-stage Hodgkin lymphoma has been associated with conflicting toxicity reports. METHODS.
Ascari E. +12 more
core +1 more source
CCNU, vinblastine, procarbazine and prednisone (CVPP) with extended-field radiotherapy in the treatment of early unfavorable Hodgkin's disease - A prospective study on behalf of the Gruppo Italiano per lo Studio dei Linfomi (GISL) [PDF]
, 1996 Purpose. To test the adequacy of the CVPP four-drug regimen as ancillary chemotherapy associated with extended-field radiotherapy in the treatment of early, unfavorable, clinically staged Hodgkin's disease. Patients and Methods.
Angrilli, F +11 more
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