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Veterinary and Comparative Oncology, 2023
Multi-agent chemotherapy successfully induces remission in most naïve, high-grade canine lymphoma patients; however, disease recurrence is common. MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) is an effective rescue protocol used to ...
Kelley Zimmerman +5 more
semanticscholar +1 more source
Multi-agent chemotherapy successfully induces remission in most naïve, high-grade canine lymphoma patients; however, disease recurrence is common. MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) is an effective rescue protocol used to ...
Kelley Zimmerman +5 more
semanticscholar +1 more source
Hypersensitivity to Mechlorethamine
Annals of Internal Medicine, 1981Excerpt To the editor: The recently published review by Weiss and Bruno (1) prompts us to report a second case of type 1 hypersensitivity to intravenous mechlorethamine.
Skaria Alexander, Kenneth S. Wilson
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Chemotherapy of Lymphoma With Mechlorethamine and Vinblastine
Archives of Internal Medicine, 1973To determine the relative efficacy of mechlorethamine hydrochloride and vinblastine sulfate, 172 patients with Hodgkin's disease, lymphosarcoma, and reticulum cell sarcoma were randomly assigned to receive one or the other of these agents. If treatment with the first compound failed, each patient was to be treated with the second.
Dennis M. Donohue +5 more
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Hyperbaric Oxygenation and Mechlorethamine Effectiveness
Archives of Surgery, 1963In order to test one of the possible radiomimetic qualities of alkylating agents, we have studied the influence of hyperbaric oxygen on the tumoricidal action of mechlorethamine (nitrogen mustard) in spontaneous mammary tumors of heterozygous, randomly bred Swiss-Webster mice.
Robert P. Leather, Charles Eckert
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, 2021
e19516 Background: There are few optimized therapeutic options for relapsed and/or refractory classic Hodgkin’s lymphoma (r/rCHL), especially in patients who failed in treatments of autologous stem cell transplantation (ASCT), brentuximab vedotin or even
Min-hang Zhou +5 more
semanticscholar +1 more source
e19516 Background: There are few optimized therapeutic options for relapsed and/or refractory classic Hodgkin’s lymphoma (r/rCHL), especially in patients who failed in treatments of autologous stem cell transplantation (ASCT), brentuximab vedotin or even
Min-hang Zhou +5 more
semanticscholar +1 more source
Topical Therapy of Psoriasis With Mechlorethamine
Archives of Dermatology, 1972Aqueous solutions of mechlorethamine (Mustargen) hydrochloride (0.055 to 0.00625%) have been used in courses of seven to ten days on lesions of psoriasis in 42 patients. A significant involutionary effect was obtained with the 0.0125% to 0.05% concentrations, particularly on the trunk. The rate of contact sensitization ranged from 50% to more than 80%,
Herschel S. Zackheim +3 more
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[14C]Mechlorethamine Binding to Proteins of the Human Keratinocyte [PDF]
Military Medicine, 1990 Much mustard agent research has focused on mustard/DNA interactions. Mustard also interacts with proteins, however, and to reach the DNA any agent must first pass through the cytoplasm. We hypothesized that the cell's proteins would covalently bind mustard, and thereby limit its access to the DNA.
Gregory P. Jones +2 more
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NMR studies of the conjugation of mechlorethamine with glutathione
Journal of Medicinal Chemistry, 1990Many cancer cells are resistant to chemotherapeutic treatment with mechlorethamine and other alkylating agents. These drug-resistant cells often show an increase in the intracellular concentration of glutathione and an increase in the activity of glutathione-S-transferase when compared to the sensitive cells.
Michael E. Colvin +2 more
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Topical mechlorethamine therapy for mycosis fungoides
British Journal of Dermatology, 1977Patients with limited skin involvement by mycosis fungoides were treated with daily topical mechlorethamine. Seven of thirteen patients had a complete remission of diseases. Six of these seven experienced a contact dermatitis and four underwent a successful topical desensitization programme.
Zvi Fuks +5 more
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