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LEDGF interacts with the NID of MeCP2 and modulates MeCP2 condensates
AbstractMethyl-CpG-binding protein 2 (MeCP2) is a ubiquitously expressed nuclear protein that is involved in transcriptional regulation and chromatin remodeling. MeCP2 exists in two isoforms, MeCP2 E1 and MeCP2 E2, which share the same functional domains. Loss-of-function mutations in the MeCP2 gene are the main cause of Rett syndrome (RTT).Saskia Lesire +8 more
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Science Signaling, 2016
The behavioral effects of loss or dysfunction of MeCP2 involve HDAC1 and -2 in the striatum and HDAC3 in the hippocampus.
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The behavioral effects of loss or dysfunction of MeCP2 involve HDAC1 and -2 in the striatum and HDAC3 in the hippocampus.
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MECP2 DUPLICATION SYNDROME WITH ADDITIONAL FINDINGS.
Genetic counseling (Geneva, Switzerland), 2016Rett syndrome (RTT) and Angelman syndrome (AS) are devastating neurological disorders that participate in overlapping clinical features with autism spectrum disorders (ASDs). It has been reported that in addition to common mutations or deletions, individuals with chromosomal duplications including either the MECP2 or UBE3A loci show clinical features ...
Perçin, Ferda Emriye +2 more
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MeCP2 Dysfunction in Humans and Mice
Journal of Child Neurology, 2005Rett syndrome is a leading cause of postnatal neurodevelopmental regression. Rett syndrome is caused by mutations in MECP2, the gene encoding methyl-CpG binding protein 2. In up to 96% of all classic cases, Rett syndrome cases are caused by mutations or deletions in MECP2.
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MeCP2: the chromatin connection and beyond
Biochemistry and Cell Biology, 2005Of the recently discovered group of proteins that interpret DNA methylation signals by preferentially associating with methylated CpG dinucleotides, the methyl-CpG-binding protein 2 (MeCP2) has attracted considerable attention in view of its ability to repress transcription.
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Sustained effects of rapidly acting antidepressants require BDNF-dependent MeCP2 phosphorylation
Nature Neuroscience, 2021Ji-Woon Kim, Anita E Autry, Elisa S Na
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MeCP2 links heterochromatin condensates and neurodevelopmental disease
Nature, 2020Charles H Li +2 more
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MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion
Science, 2021Abdulkhaleg Ibrahim +2 more
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