Results 231 to 240 of about 27,643 (268)

MeCP2: the chromatin connection and beyond

Biochemistry and Cell Biology, 2005
Of the recently discovered group of proteins that interpret DNA methylation signals by preferentially associating with methylated CpG dinucleotides, the methyl-CpG-binding protein 2 (MeCP2) has attracted considerable attention in view of its ability to repress transcription.
openaire   +2 more sources

MeCP2 and drug addiction

Nature Neuroscience, 2010
Two studies in this issue show that the protein MeCP2, which is implicated in Rett syndrome, also critically regulates behavioral responses to psychostimulants. Although the two studies highlight different mechanisms of MeCP2 in regulating these behaviors, both underscore the importance of epigenetic mechanisms in establishing drug addiction.
Jian Feng, Eric J Nestler
openaire   +1 more source

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Nature Genetics, 1999
R. Amir, I. B. Van den Veyver, Mimi Wan, Charles Q. Tran, U. Francke, H. Zoghbi   +5 more
semanticscholar   +1 more source

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Nature, 1998
Xin-Sheng Nan, H. Ng, Colin A. Johnson, C. D. Laherty, B. Turner, R. Eisenman, A. Bird   +6 more
semanticscholar   +1 more source

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

Nature Genetics, 1998
P. Jones, Gert C. Jan Veenstra, P. Wade, D. Vermaak, S. Kass, N. Landsberger, J. Strouboulis, A. Wolffe   +7 more
semanticscholar   +1 more source

MECP2 DUPLICATION SYNDROME WITH ADDITIONAL FINDINGS.

Genetic counseling (Geneva, Switzerland), 2016
Rett syndrome (RTT) and Angelman syndrome (AS) are devastating neurological disorders that participate in overlapping clinical features with autism spectrum disorders (ASDs). It has been reported that in addition to common mutations or deletions, individuals with chromosomal duplications including either the MECP2 or UBE3A loci show clinical features ...
Perçin, Ferda Emriye, Tuğ, Esra, Ergün, Mehmet Ali   +2 more
openaire   +3 more sources

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

Nature Genetics, 2001
J. Guy, B. Hendrich, M. Holmes, Joanne E. Martin, A. Bird   +4 more
semanticscholar   +1 more source

Exploring the complexity of MECP2 function in Rett syndrome

Nature Reviews Neuroscience
Yi Liu, Troy W. Whitfield, George W. Bell, Rui-Si Guo, Anthony Flamier, Richard A. Young, Rudolf Jaenisch   +6 more
semanticscholar   +1 more source

MeCP2

2013
Vani Brahmachari, Shruti Jain
openaire   +1 more source

Pharmacological Reversal of Synaptic and Network Pathology in Human MECP2‐KO Neurons and Cortical Organoids

EMBO Molecular Medicine, 2021
Fabian Zanella, Priscilla D Negraes, Terrence J. Sejnowski   +2 more
exaly