Results 71 to 80 of about 33,901 (278)

A central role for MeCP2 in the epigenetic repression of miR-200c during epithelial-to-mesenchymal transition of glioma

Journal of Experimental & Clinical Cancer Research, 2019
Background The epithelial-to-mesenchymal transition (EMT) has been linked to the regulation of glioma progression. However, the underlying signaling mechanisms that regulate EMT are poorly understood.
Erbao Bian, Xueran Chen, Yadi Xu, Xinghu Ji, Meng Cheng, Hongliang Wang, Zhiyou Fang, Bing Zhao   +7 more
doaj   +1 more source

Evidence of neuronal DNA damage in the brains of patients with Rett syndrome

Disease Models & Mechanisms
Abril Morales, Elena Korsakova, Niloufar Mansooralavi, Peter Soliman, Sarvin Jahanbani, Michelle L. Olsen, Aparna Badhuri, William E. Lowry   +7 more
doaj   +2 more sources

MeCP2 confers 5-fluorouracil resistance in gastric cancer via upregulating the NOX4/PKM2 pathway

Cancer Cell International, 2022
Background Increasing evidence suggests that aberrant methylation is involved in 5-fluorouracil (5-FU) resistance in gastric cancer (GC). Our previous work has identified that Methyl-CpG binding protein 2 (MeCP2) promotes GC progression by binding to the
Yannan Qin, Xiaoping Ma, Chen Guo, Shuang Cai, Hailin Ma, Lingyu Zhao   +5 more
doaj   +1 more source

Role of miR-132/methyl-CpG-binding protein 2 in the regulation of neural stem cell differentiation

Neural Regeneration Research, 2021
Methyl-CpG-binding protein 2 (MeCP2) is a well-known transcription repressor, and mutations in MECP2 cause serious neurological disorders. Many studies have suggested that MeCP2 is involved in neural maturation only, and have not reported its role in ...
Dong Chen, Jie Liu, Zhong Wu, Shao-Hua Li   +3 more
doaj   +1 more source

Exaggerated CpH methylation in the autism-affected brain. [PDF]

, 2017
BackgroundThe etiology of autism, a complex, heritable, neurodevelopmental disorder, remains largely unexplained. Given the unexplained risk and recent evidence supporting a role for epigenetic mechanisms in the development of autism, we explored the ...
Arking, Dan E, Ellis, Shannon E, Gupta, Simone, Moes, Anna, West, Andrew B   +4 more
core   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing [PDF]

Bioscience Reports, 2011
Mutations in MECP2 (methyl-CpG-binding protein 2) are linked to the severe postnatal neurodevelopmental disorder RTT (Rett syndrome). MeCP2 was originally characterized as a transcriptional repressor that preferentially bound methylated DNA; however, recent results indicate MeCP2 is a multifunctional protein.
Long, Steven W., Ooi, Jenny Y. Y., Yau, Peter M., Jones, Peter L.   +3 more
openaire   +3 more sources

Zebrafish mecp2 null-mutation increases anxiety and cortisol levels but no change in adult social preference and larval chemically-induced hyperlocomotion

BMC Neuroscience
Background Methyl CpG binding protein 2 (MECP2) is an essential global modulator of transcription and mutations in MECP2 are the most common cause of Rett syndrome, an X-linked neurodevelopmental disorder.
Soaleha Shams, Pierre Cronell, Jenny Landin, Thomas Pietri, Adrian Ekehorn Gimdal, Petronella Kettunen, Lars Westberg   +6 more
doaj   +1 more source

Exosomes regulate neurogenesis and circuit assembly. [PDF]

, 2019
Exosomes are thought to be released by all cells in the body and to be involved in intercellular communication. We tested whether neural exosomes can regulate the development of neural circuits.
Carromeu, Cassiano, Cline, Hollis T, McClatchy, Daniel R, Mesci, Pinar, Muotri, Alysson R, Schiapparelli, Lucio, Sharma, Pranav, Yates, John R   +7 more
core  

Impaired CO2 sensitivity of astrocytes in a mouse model of Rett syndrome [PDF]

, 2015
Rett syndrome is a prototypical neurological disorder characterised by abnormal breathing pattern and reduced ventilatory CO2 sensitivity. Medullary astrocytes are a crucial component of central CO2 /pH chemosensitivity.
Abdala, AP, Gourine, AV, Karagiannis, A, Turovsky, E   +3 more
core   +1 more source