Results 51 to 60 of about 27,643 (268)

Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity

Epigenetics, 2017
MeCP2 binds to methylated DNA in a chromatin context and has an important role in cancer and brain development and function. Histone deacetylase (HDAC) inhibitors are currently being used to palliate many cancer and neurological disorders.
Katrina V. Good, Alexia Martínez de Paz, Monica Tyagi, Manjinder S. Cheema, Anita A. Thambirajah, Taylor L. Gretzinger, Gilda Stefanelli, Robert L. Chow, Oliver Krupke, Michael Hendzel, Kristal Missiaen, Alan Underhill, Nicoletta Landsberger, Juan Ausió   +13 more
doaj   +1 more source

A role for MeCP2 in switching gene activity via chromatin unfolding and HP1γ displacement.

PLoS ONE, 2013
Methyl-CpG-binding protein 2 (MeCP2) is generally considered to act as a transcriptional repressor, whereas recent studies suggest that MeCP2 is also involved in transcription activation.
Maartje C Brink, Diewertje G E Piebes, Marloes L de Groote, Martijn S Luijsterburg, Corella S Casas-Delucchi, Roel van Driel, Marianne G Rots, M Cristina Cardoso, Pernette J Verschure   +8 more
doaj   +1 more source

Rett Syndrome Mutant Neural Cells Lacks MeCP2 Immunoreactive Bands. [PDF]

PLoS ONE, 2016
Dysfunctions of MeCP2 protein lead to various neurological disorders such as Rett syndrome and Autism. The exact functions of MeCP2 protein is still far from clear. At a molecular level, there exist contradictory data.
Carlos Bueno, Rafael Tabares-Seisdedos, Jose M Moraleda, Salvador Martinez   +3 more
doaj   +1 more source

Descending serotonergic controls regulate inflammation-induced induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal horn [PDF]

, 2008
Background: Regulation of pain states is, in part, dependent upon plastic changes in neurones within the superficial dorsal horn. There is also compelling evidence that pain states are under the control of descending projections from the brainstem. While
Geranton, SM, Hunt Stephen P, Vincenza Fratto, Fratto Vincenza, Fratto, V, Tochiki Keri K, Géranton Sandrine M, Hunt, SP, Sandrine M Géranton, Keri K Tochiki, Stephen P Hunt, Tochiki, KK   +11 more
core   +1 more source

MeCP2 Repression Goes Nonglobal [PDF]

Science, 2003
Methylation of CpG islands in gene promoters results in silencing of those genes. Mutation of a methyl-CpG binding domain protein called MeCP2 that contributes to the maintenance of methylation-mediated gene silencing is associated with a severe neurological disease called Rett syndrome.
Klose, Robert, Bird, Adrian P
openaire   +4 more sources

The Effect of Mecp2 on Heart Failure [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: Heart failure is the end result of various kinds of cardiovascular diseases. It has a high rate of morbidity and mortality. This article aims to determine the effect of MeCP2, a key epigenetic regulator, on heart failure. Methods: The genes associated with heart failure were selected and analyzed using Gene Ontology (GO) term analysis ...
Chunli Wang, Fei Wang, Qing Cao, Zhen Li, Liya Huang, Shuyan Chen   +5 more
openaire   +3 more sources

MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity

FEBS Open Bio, 2015
Nerve injury induces chronic pain and dysregulation of microRNAs in dorsal root ganglia (DRG). Several downregulated microRNAs are predicted to targetMecp2. MECP2 mutations cause Rett syndrome and these patients report decreased pain perception.
Melissa T. Manners, Yuzhen Tian, Zhaolan Zhou, Seena K. Ajit   +3 more
doaj   +1 more source

Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation

Neurobiology of Disease, 2009
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the gene MECP2, encoding methyl-CpG-binding protein 2 (MeCP2). Few studies have explored dendritic morphology phenotypes in mouse models of RTT and none have determined
Nadia P. Belichenko, Pavel V. Belichenko, William C. Mobley   +2 more
doaj   +1 more source

Understanding intellectual disability and autism spectrum disorders from common mouse models: synapses to behaviour [PDF]

Open Biology, 2019
Normal brain development is highly dependent on the timely coordinated actions of genetic and environmental processes, and an aberration can lead to neurodevelopmental disorders (NDDs).
Vijaya Verma, Abhik Paul, Anjali Amrapali Vishwanath, Bhupesh Vaidya, James P. Clement   +4 more
doaj   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability [PDF]

Advanced science
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Kong Y, Zhou W, Sun Y, Huang Z, Liu Z, Kumar. S U, Li C, Lu Y, Song C, Ciliberto V, Mack M, Kim L, Hu Z, Luo F, Cao A, Sun Z.   +15 more
europepmc   +2 more sources