Results 71 to 80 of about 27,643 (268)

MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis

Advancement of science
Lactate plays diverse roles in brain pathophysiology, including ischemic stroke. Here, the role of lysine lactylation, an epigenetic modification of lactate, in cerebral ischemia is investigated.
Min Sun, Yuxin Zhang, Rui Mao, Yan Chen, Pin-Yi Liu, Lei Ye, Si-yi Xu, Jun-qiu Jia, Shu Shu, Hui-Ya Li, Yanping Yin, Sheng-Nan Xia, Yan-Ting Chen, Yun Xu   +13 more
semanticscholar   +1 more source

circFOXM1 contributes to sorafenib resistance of hepatocellular carcinoma cells by regulating MECP2 via miR-1324

Molecular Therapy: Nucleic Acids, 2021
As one of the most common malignant tumors, hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths around the world. Emerging studies have indicated that circular RNAs (circRNAs), which play a crucial role in HCC pathogenesis and ...
Han-Qin Weng, Lexiang Zeng, Linhui Cao, Tao Chen, Yan-Shan Li, Yunxiuxiu Xu, Yao-Rong Peng, Yi-Biao Ye   +7 more
semanticscholar   +1 more source

Macrophage‐targeted delivery of siRNA to silence Mecp2 gene expression attenuates pulmonary fibrosis

Bioengineering & Translational Medicine, 2021
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by the infiltration of macrophages in the fibrotic region. Currently, no therapeutic strategies effectively control disease progression, and the 5‐year mortality
Yong Mou, Guo-Rao Wu, Qi Wang, T. Pan, Lei Zhang, Yong-Jian Xu, W. Xiong, Qing Zhou, Yi Wang   +8 more
semanticscholar   +1 more source

Regulation of transient receptor potential vanilloid 1 expression in trigeminal ganglion neurons via methyl-CpG binding protein 2 signaling contributes tongue heat sensitivity and inflammatory hyperalgesia in mice

Molecular Pain, 2016
Background Pain hypoalgesia has been reported in Rett syndrome patients, a severe neurodevelopmental disorder which can be attributed to mutations in the methyl-CpG binding protein 2 (MeCP2).
Azumi Suzuki DDS, Masamichi Shinoda DDS, PhD, Kuniya Honda DDS, PhD, Tetsuro Shirakawa DDS, PhD, Koichi Iwata DDS, PhD   +4 more
doaj   +1 more source

Mutation of MeCP2 at T158M Leads to Distinct Molecular and Phenotypic Abnormalities in Male and Female Mice

Cells
Methyl CpG-binding protein 2 (MeCP2) is an epigenetic reader of DNA methylation with high abundance in the brain. While genetic mutations occur across different protein domains of MeCP2, the T158M mutation is amongst the most frequent MeCP2 mutations ...
Chris-Tiann Roberts, Ashraf Kadar Shahib, Khatereh Saei Arezoumand, Ghanan Bin Akhtar, Kazem Nejati-Koshki, Jessica S. Jarmasz, Seyyed Mohyeddin Ziaee, Marjorie Buist, Nicole Raabe, Abbas Rezaeian Mehrabadi, Carl O. Olson, Mojgan Rastegar   +11 more
doaj   +1 more source

MeCP2 Plays an Analgesic Role in Pain Transmission through Regulating CREB / miR-132 Pathway

Molecular Pain, 2015
Background The Methyl CpG binding protein 2 gene (MeCP2 gene) encodes a critical transcriptional repressor and is widely expressed in mammalian neurons. MeCP2 plays a critical role in neuronal differentiation, neural development, and synaptic plasticity.
Ran Zhang, Min Huang, Zhijuan Cao, Jieyu Qi, Zilong Qiu, Li-Yang Chiang   +5 more
doaj   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

A Temporal Threshold for Formaldehyde Crosslinking and Fixation [PDF]

, 2009
Background: Formaldehyde crosslinking is in widespread use as a biological fixative for microscopy and molecular biology. An assumption behind its use is that most biologically meaningful interactions are preserved by crosslinking, but the minimum length
Schmiedeberg, Lars, Skene, Pete, Skene Pete, Bird Adrian, Lars Schmiedeberg, Pete Skene, Deaton Aimée, Schmiedeberg Lars, Adrian Bird, Aimée Deaton, Deaton, Aimee, Bird, Adrian; id_orcid   +11 more
core   +2 more sources

The MECP2 duplication syndrome [PDF]

American Journal of Medical Genetics Part A, 2010
AbstractIn this review, we detail the history, molecular diagnosis, epidemiology, and clinical features of the MECP2 duplication syndrome, including considerations for the care of patients with this X‐linked neurodevelopmental disorder. MECP2 duplication syndrome is 100% penetrant in affected males and is associated with infantile hypotonia, severe to ...
Melissa B, Ramocki, Y Jane, Tavyev, Sarika U, Peters   +2 more
openaire   +2 more sources

MeCP2 dependent heterochromatin reorganization during neural differentiation of a novel Mecp2-deficient embryonic stem cell reporter line.

PLoS ONE, 2012
The X-linked Mecp2 is a known interpreter of epigenetic information and mutated in Rett syndrome, a complex neurological disease. MeCP2 recruits HDAC complexes to chromatin thereby modulating gene expression and, importantly regulates higher order ...
Bianca Bertulat, Maria Luigia De Bonis, Floriana Della Ragione, Anne Lehmkuhl, Manuela Milden, Christian Storm, K Laurence Jost, Simona Scala, Brian Hendrich, Maurizio D'Esposito, M Cristina Cardoso   +10 more
doaj   +1 more source