Results 41 to 50 of about 27,643 (268)
Regulation of BDNF transcription by Nrf2 and MeCP2 ameliorates MPTP-induced neurotoxicity
Cell Death Discovery, 2022 Mounting evidence suggests the key role of brain-derived neurotrophic factor (BDNF) in the dopaminergic neurotoxicity of Parkinson’s disease (PD). Activation of NF-E2-related factor-2 (Nrf2) and inhibition of methyl CpG-binding protein 2 (MeCP2) can ...
Qianqian Cao +10 more
semanticscholar +1 more source
The Role of MeCP2 in Regulating Synaptic Plasticity in the Context of Stress and Depression
Cells, 2022 Methyl-CpG-binding protein 2 (MeCP2) is a transcriptional regulator that is highly abundant in the brain. It binds to methylated genomic DNA to regulate a range of physiological functions implicated in neuronal development and adult synaptic plasticity ...
C. Sánchez-Lafuente +3 more
semanticscholar +1 more source
Large genomic rearrangements in MECP2 [PDF]
Human Mutation, 2005 In 1999, mutations in the X-linked gene methyl-CpG-binding protein 2 (MECP2) were first reported in patients with Rett syndrome (RTT). The MECP2 gene is located at Xq28 and consists of 4 exons. About 80-90 % of the classic RTT patients harbor mutations in the coding region of MECP2, while the molecular cause is unknown in the remaining 10-20%.
Kirstine, Ravn +5 more
openaire +2 more sources
Role of DNA Methyl-CpG-Binding Protein MeCP2 in Rett Syndrome Pathobiology and Mechanism of Disease
Biomolecules, 2021 Rett Syndrome (RTT) is a severe, rare, and progressive developmental disorder with patients displaying neurological regression and autism spectrum features. The affected individuals are primarily young females, and more than 95% of patients carry de novo
S. Pejhan, M. Rastegar
semanticscholar +1 more source
, 2023 MeCP2 is a transcriptional regulator that is involved in epithelial-mesenchymal transition (EMT) and is highly expressed in proliferative vitreoretinopathy. m6A methylation is a critical post-transcriptional regulation in eukaryotic cells.
Yongya Zhang (2555647) +5 more
core +1 more source
MeCP2 as an Activator of Gene Expression [PDF]
Trends in Neurosciences, 2018 Rett syndrome is a neurodevelopmental disorder that primarily affects females and is caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and colleagues (DOI: 10.1126/science.1153252) reported that MeCP2 could also function as a ...
Patricia M, Horvath, Lisa M, Monteggia
openaire +2 more sources
Methyl-CpG binding protein 2 (Mecp2) Regulates Sensory Function through Sema5b and Robo2
Frontiers in Cellular Neuroscience, 2015 Mutations in the gene encoding the MECP2 underlies Rett syndrome, a neurodevelopmental disorder in young females. Although reduced pain sensitivity in Rett syndrome patients and in partial MeCP2 deficient mice had been reported, these previous studies ...
Wan Ying eLeong +4 more
doaj +1 more source
Journal of Integrative Neuroscience, 2022 Background: Rett syndrome is a rare genetic neurological syndrome that affects mostly females. The syndrome leads to severe impairments impacting all areas of the affected persons' life, including speech, mobility, eating, and breathing impairments.
Alen Kapel +3 more
doaj +1 more source
Disease modelling of a human neurodevelopmental disorder using mouse embryonic stem cells [PDF]
, 2011 As cultured embryonic stem (ES) cells can be differentiated in neurons under well-defined conditions, they provide a unique opportunity to model and study diseases of the nervous system such as Rett syndrome.
Yazdani Shektaei, Morteza
core +1 more source
MeCP2: a novel Huntingtin interactor [PDF]
Human Molecular Genetics, 2013 Transcriptional dysregulation has been proposed to play a major role in the pathology of Huntington's disease (HD). However, the mechanisms that cause selective downregulation of target genes remain unknown. Previous studies have shown that mutant huntingtin (Htt) protein interacts with a number of transcription factors thereby altering transcription ...
McFarland KN +7 more
openaire +4 more sources