Results 21 to 30 of about 27,643 (268)
MeCP2 interacts with chromosomal microRNAs in brain
Epigenetics, 2017 Although methyl CpG binding domain protein-2 (MeCP2) is commonly understood to function as a silencing factor at methylated DNA sequences, recent studies also show that MeCP2 can bind unmethylated sequences and coordinate gene activation.
Abdul Waheed Khan +5 more
doaj +3 more sources
The Role of MeCP2 in the Brain
Annual Review of Cell and Developmental Biology, 2011 Methyl-CpG binding protein 2 (MeCP2) was first identified in 1992 as a protein that binds specifically to methylated DNA. Mutations in the MECP2 gene were later found to be the cause of an autism spectrum disorder, Rett syndrome. Despite almost 20 years
Jim Selfridge +3 more
core +3 more sources
The Molecular Basis of MeCP2 Function in the Brain.
Journal of Molecular Biology, 2020 MeCP2 is a reader of the DNA methylome that occupies a large proportion of the genome due to its high abundance and the frequency of its target sites.
R. Tillotson, A. Bird
semanticscholar +3 more sources
MeCP2 modulates gene expression pathways in astrocytes [PDF]
Molecular Autism, 2013 Background Mutations in MECP2 encoding methyl-CpG-binding protein 2 (MeCP2) cause the X-linked neurodevelopmental disorder Rett syndrome. Rett syndrome patients exhibit neurological symptoms that include irregular breathing, impaired mobility ...
Yasui Dag H +5 more
doaj +2 more sources
Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome
Neurobiology of Disease, 2014 Rett syndrome (RTT) is a rare neurodevelopmental disorder affecting almost exclusively females, caused in the overwhelming majority of the cases by loss-of-function mutations in the gene encoding methyl-CpG binding protein 2 (MECP2).
Claudio De Felice +22 more
doaj +2 more sources
Genetic modifiers of MeCP2 function in Drosophila.
PLoS Genetics, 2008 The levels of methyl-CpG-binding protein 2 (MeCP2) are critical for normal post-natal development and function of the nervous system. Loss of function of MeCP2, a transcriptional regulator involved in chromatin remodeling, causes classic Rett syndrome ...
Holly N Cukier +5 more
doaj +2 more sources
Molecular Genetic Analysis and Prenatal Diagnosis of a Family With MECP2 Duplication Syndrome. [PDF]
J Clin Lab AnalCombined low‐pass CNV‐seq and MLPA identified an inherited Xq28 duplication encompassing MECP2 in a 15‐week male fetus and his affected older brother, transmitted from an asymptomatic mother. This integrated strategy enabled accurate pedigree analysis and prenatal diagnosis of MECP2 duplication syndrome, supporting genetic counseling and reproductive ...
Lin F +9 more
europepmc +2 more sources
Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2 [PDF]
Proceedings of the National Academy of Sciences, 2007 In humans, mutations in the X-linked MECP2 gene, are the cause of Rett syndrome (RTT), a neurodevelopmental disorder that affects mainly girls. MeCP2 binds to methylated CpGs and is thought to act as a transcriptional repressor. In male mice, deletion or targeted mutation of
Emanuela, Giacometti +3 more
openaire +2 more sources
The Epigenetic Reader Methyl-CpG-Binding Protein 2 (MeCP2) Is an Emerging Oncogene in Cancer Biology
Cancers, 2023 Simple Summary Methyl-CpG binding protein 2 (MeCP2) is a nuclear protein that is mainly studied for its role as an epigenetic regulator of gene transcription.
Kazem Nejati-Koshki +3 more
semanticscholar +1 more source
Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons
bioRxiv, 2022 Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by loss-of-function heterozygous mutations of Methyl CpG-binding Protein 2 (MECP2) on the X chromosome in girls.
Jun-Ming Qian +9 more
semanticscholar +1 more source