Results 1 to 10 of about 27,643 (268)

MeCP2-induced heterochromatin organization is driven by oligomerization-based liquid–liquid phase separation and restricted by DNA methylation

Nucleus, 2022
Heterochromatin is the highly compacted form of chromatin with various condensation levels hallmarked by high DNA methylation. MeCP2 is mostly known as a DNA methylation reader but has also been reported as a heterochromatin organizer.
Hui Zhang, Hector Romero, Annika Schmidt, Katalina Gagova, Weihua Qin, Bianca Bertulat, Anne Lehmkuhl, Manuela Milden, Malte Eck, Tobias Meckel, Heinrich Leonhardt, M. Cristina Cardoso   +11 more
doaj   +3 more sources

Disruption of MeCP2–TCF20 Complex Underlies Distinct Neurodevelopmental Disorders

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Loss-of-function mutations in MECP2 cause the neurological disorder Rett syndrome (RTT), but the precise molecular mechanism driving pathogenesis remains unclear.
Tobias Haack, Shao Yingyao, Michelle L Thompson   +2 more
exaly   +3 more sources

MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation

Nature Communications, 2023
Correlative evidence has suggested that the methyl-CpG-binding protein MeCP2 contributes to the formation of heterochromatin condensates via liquid-liquid phase separation.
Raphaël Pantier, Megan Brown, Sicheng Han, Katie Paton, Stephen Meek, Thomas Montavon, Nicholas Shukeir, Toni McHugh, David A. Kelly, Tino Hochepied, Claude Libert, Thomas Jenuwein, Tom Burdon, Adrian Bird   +13 more
doaj   +2 more sources

The Molecular Functions of MeCP2 in Rett Syndrome Pathology

Frontiers in Genetics, 2021
MeCP2 protein, encoded by the MECP2 gene, binds to DNA and affects transcription. Outside of this activity the true range of MeCP2 function is still not entirely clear.
Osman Sharifi, Dag H. Yasui
doaj   +2 more sources

MECP2 Directly Interacts With RNA Polymerase II to Modulate Transcription in Human Neurons

Neuron
Mutations in the methyl-DNA-binding protein MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). How MECP2 contributes to transcriptional regulation in normal and disease states is unresolved; it has been reported to be an activator and a ...
Yi Liu, Anthony Flamier, George W. Bell, A. J. Diao, Troy W. Whitfield, Hao-Che Wang, Yizhe Wu, Fabian Schulte, Max Friesen, Rui-Si Guo, M. Mitalipova, X. S. Liu, S. Vos, Richard A. Young, Rudolf Jaenisch   +14 more
exaly   +2 more sources

MeCP2 functions as a DNA methylation reader in immune homeostasis and cancer [PDF]

Frontiers in Epigenetics and Epigenomics
DNA methylation is a key epigenetic mechanism that mediates gene expression and informs cellular identity. Methyl-CpG binding protein 2 (MeCP2) is a protein capable of recognizing and interpreting the methylated DNA code to bring about phenotypic ...
Grace C. Stroman, Grace C. Stroman, Clara Mellows, Clara Mellows, Kevin Pruitt, Kevin Pruitt   +5 more
doaj   +2 more sources

Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice

Experimental and Molecular Medicine, 2023
Mounting evidence suggests that probiotics are beneficial for treating Alzheimer’s disease (AD). However, the mechanisms by which specific probiotics modify AD pathophysiology are not clearly understood.
Hye-Joo Kwon, Eun-Hwa Lee, So-Young Park, Jin-Young Park, Jin-Hwan Hong, Eun-Kyung Kim, Tae-Seop Shin, Yoon Kim, P. Han   +8 more
semanticscholar   +1 more source

MeCP2 Is an Epigenetic Factor That Links DNA Methylation with Brain Metabolism

International Journal of Molecular Sciences, 2023
DNA methylation, one of the most well-studied epigenetic modifications, is involved in a wide spectrum of biological processes. Epigenetic mechanisms control cellular morphology and function.
Yen My Vuu, Chris-Tiann Roberts, M. Rastegar   +2 more
semanticscholar   +1 more source

Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation

Cell Reports, 2023
SUMMARY Mutations in the MECP2 gene underlie a spectrum of neurodevelopmental disorders, most commonly Rett syndrome (RTT). We ask whether MECP2 mutations interfere with human astrocyte developmental maturation, thereby affecting their ability to support
Jia-Lin Sun, S. Osenberg, Austin Irwin, Li-Hua Ma, Nigel Lee, Yang-Fei Xiang, Feng Li, Y. Wan, In-Hyun Park, M. Maletić-Savatić, N. Ballas   +10 more
semanticscholar   +1 more source

Rare Variants in the MECP2 Gene in Girls with Central Precocious Puberty

The Lancet Diabetes and Endocrinology, 2023
Background Identification of genetic causes of central precocious puberty (CPP) has revealed epigenetic mechanisms as regulators of human pubertal timing. Methyl-CpG-binding protein 2 (MECP2), an X-linked gene, encodes a chromatin-associated protein with
A. Canton, F. Tinano, L. Guasti, L. Montenegro, F. Ryan, Deborah Shears, M. E. de Melo, L. Gomes, Mariana P. Piana, R. Brauner, R. E. Aguilar, Arancha Escribano-Muñoz, A. Paganoni, Jordan E. Read, M. Korbonits, C. Seraphim, S. Costa, A. Krepischi, A. Jorge, A. David, L. R. Kaisinger, Ken K. Ong, J. Perry, A. Abreu, U. Kaiser, J. Argente, B. Mendonça, V. Brito, S. Howard, A. Latronico   +29 more
semanticscholar   +1 more source