Results 91 to 100 of about 4,586,937 (332)

Accesibilidad a los videojuegos : estado actual y perspectivas futuras [PDF]

, 2011
Durante los últimos años la accesibilidad a los medios de comunicación ha adquirido gran relevancia, impulsada por el cambio de la televisión analógica a la digital programado en Europa para el año 2012.
Mangiron i Hevia, Carme
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Media and Polarization [PDF]

This paper provides a model of how media environments affect political polarization. We first develop a model of how media environments, characterized by their levels of accessibility and variety of content, interact with citizens' ideological views and ...
Campante, Filipe R., Hojman, Daniel
core   +1 more source

A Study of Accessibility Requirements for Media Players on the Web [PDF]

, 2011
Proceedings of: The 6th International Conference on Universal Access in Human–Computer Interaction (UAHCI 2011), held as part of The 14th International Conference on Human–Computer Interaction (HCI International 2011), Orlando (FL, USA), July 9-14 ...
González, María, Iglesias, Ana, Martínez, Paloma, Moreno, Lourdes   +3 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Compliance with web content accessibility guidelines in ophthalmology social media posts

Scientific Reports
This is a cross-sectional exploratory analysis of publicly available Internet data to examine compliance to web content accessibility guidelines (WCAG) on patient education social media posts in ophthalmology.
Meghan Sharma, Laura Huertas, Serena Shah, Alexandra Gil, Elena Bitrian, Ta C. Chang   +5 more
doaj   +1 more source

Mapping the Evolving Landscape of Audiovisual Translation and Media Accessibility

Anglica. An International Journal of English Studies
This article explores the dynamic evolution of audiovisual translation (AVT) and media accessibility amid technological advances and shifting societal expectations.
Monika Zabrocka
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source