Results 71 to 80 of about 4,586,937 (332)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Audio Describing Humour in Persian: The Case of Shaun the Sheep, Road Runner and The Pink Panther
JoSTrans: The Journal of Specialised TranslationAudio description (AD) has been a topic of high interest among translation studies researchers in the past two decades. Despite this, certain aspects of AD have been left unexplored, especially in non-European settings.
Masoomeh Helal Birjandi +2 more
doaj +1 more source
Raising awareness of the accessibility challenges in mathematics MOOCs [PDF]
, 2017 MOOCs provide learning environments that make it easier for learners to study from anywhere, at their own pace and with open access to content. This has revolutionised the field of eLearning, but accessibility continues to be a problem, even more so if ...
Amado-Salvatierra H. R. +12 more
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Les TIC, les médias sociaux et les étudiants et diplômés canadiens en situation de handicap
Terminal, 2014 The objective of this paper is to investigate how social media have been used by 133 students and 20 graduates who are disabled and studying in postsecondary Canadian institutions, and to analyse the accessibility of these tools.
Mai Nhu Nguyen +3 more
doaj +1 more source
Trends and determinants of contraceptive method choice in Kenya
, 2003 This paper uses data from the 1989, 1993 and 1998 Kenya Demographic and Health Surveys to examine trends and determinants of contraceptive method choice.
Curtis, Siân L., Magadi, Monica A.
core +1 more source
SMIL State: an architecture and implementation for adaptive time-based web applications [PDF]
, 2009 In this paper we examine adaptive time-based web applications (or presentations). These are interactive presentations where time dictates which parts of the application are presented (providing the major structuring paradigm), and that require ...
D Bulterman +3 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Challenges and Solutions Towards Accessible MOOC Content: The ACT MOOC [PDF]
, 2018 Designing a MOOC on accessibility poses many challenges. It is also a great platform to test what the MOOC preaches: media accessibility. This article presents the challenges and solutions taken when an accessible MOOC for Coursera was designed and ...
Black, Sharon +2 more
core +3 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source