Results 71 to 80 of about 5,601,650 (302)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Maize Silage Kernel Fragment Estimation Using Deep Learning-Based Object Recognition in Non-Separated Kernel/Stover RGB Images

Sensors, 2019
Efficient and robust evaluation of kernel processing from corn silage is an important indicator to a farmer to determine the quality of their harvested crop. Current methods are cumbersome to conduct and take between hours to days.
Christoffer Bøgelund Rasmussen, Thomas B. Moeslund   +1 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Building documentation methods for deep energy retrofits: a cross-disciplinary scoping review for exterior envelope approaches

Frontiers in Built Environment
IntroductionA meaningful reduction of carbon emissions in Canada’s Architecture Engineering Construction, Owner, and Operator (AECOO) industry must incorporate strategies for both new and existing buildings. In the case of existing buildings, Deep Energy
Kristine Prochnau, Damiano Aiello, Sena Kurcenli Koyunlu, Michael Jemtrud, Stephen Fai   +4 more
doaj   +1 more source

Exploring Deep Recurrent Q-Learning for Navigation in a 3D Environment

EAI Endorsed Transactions on Creative Technologies, 2018
Learning to navigate in 3D environments from raw sensory input is an important step towards bridging the gap between human players and artificial intelligence in digital games.
Rasmus Kongsmar Brejl, Henrik Purwins, Henrik Schoenau-Fog   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Comparative Analysis of Postmodern Architectural Expression in Egyptian University Campuses: Functional, Environmental, and Symbolic Dimensions [PDF]

JES: Journal of Engineering Sciences
Postmodern design in Egyptian university campuses blends symbolism and eclectic form, yet often neglects environmental and functional performance. This study provides a novel, performance-based comparative analysis of two postmodern campuses in Greater ...
Hanaa Elsabbagh, Samar Ahmed
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source